5-羟色胺受体 2A 基因-1438A/G 多态性与焦虑相关特征的关联研究。
Association Study of a Serotonin Receptor 2A Gene -1438A/G Polymorphism and Anxiety-Related Traits.
机构信息
Department of Obstetrics Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
Psychiatry Investig. 2008 Dec;5(4):244-6. doi: 10.4306/pi.2008.5.4.244. Epub 2008 Dec 31.
OBJECTIVE
The aim of this study was to investigate the relationship between the -1438A/G polymorphism of serotonin receptor 2A (5HTR2A) and anxiety-related traits in Korean adolescent females.
METHODS
A total of 174 Korean adolescent females were tested for the -1438A/G polymorphism of 5HTR2A using polymerase chain reaction (PCR)-based methods. Anxiety-related traits were evaluated using the Anxiety Sensitivity Index (ASI) and the trait form of the Spielberg State-Trait Anxiety Inventory (T-STAI).
RESULTS
There was no difference between the genotypes with respect to scores pertaining to anxiety-related traits. Although the G allele carriers (GG or AG genotype) scored lower on the psychological subscale of the ASI (4.76+/-3.00 vs 5.98+/-4.00, p=0.038), this difference was not significant after Bonferroni correction.
CONCLUSION
These findings suggest that the -1438A/G polymorphism of 5HTR2A might not be associated with anxiety sensitivity or trait anxiety.
目的
本研究旨在探讨韩国青春期女性 5-羟色胺受体 2A（5HTR2A）-1438A/G 多态性与焦虑相关特征之间的关系。
方法
采用聚合酶链反应（PCR）方法对 174 名韩国青春期女性进行 5HTR2A-1438A/G 多态性检测。采用焦虑敏感指数（ASI）和 Spielberg 状态-特质焦虑问卷特质形式（T-STAI）评估焦虑相关特征。
结果
基因型与焦虑相关特征评分无差异。尽管 G 等位基因携带者（GG 或 AG 基因型）在 ASI 的心理分量表上得分较低（4.76+/-3.00 对 5.98+/-4.00，p=0.038），但经 Bonferroni 校正后差异无统计学意义。
结论
这些发现表明，5HTR2A 的-1438A/G 多态性可能与焦虑敏感性或特质焦虑无关。
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