Department of Ultrasound in Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, P.R China.
Korean J Radiol. 2010 Jan-Feb;11(1):75-83. doi: 10.3348/kjr.2010.11.1.75. Epub 2009 Dec 28.
To determine whether contrast-enhanced harmonic ultrasonography can be used to predict the aggressiveness of prostate cancer.
Contrast-enhanced harmonic ultrasonography was performed in 103 patients suspected of prostate cancer before biopsy. Time intensity curves were reconstructed for systematic biopsy sites and sonographic abnormalities. The characteristics of the curves were described using hemodynamic indices including arrival time (AT), time-to-peak (TTP), and peak intensity (PI). The differences of hemodynamic indices between high-grade and low-grade cancer were analyzed and the correlations between the hemodynamic indices and biopsy Gleason score were studied.
Prostate cancer was detected in 41 of 103 patients and there were significant differences in the hemodynamic indices between the biopsy sites of the non-malignant patients and prostate cancer lesions (p < 0.05). The prostate biopsies revealed 154 prostate cancer lesions, including 31 low-grade lesions and 123 high-grade lesions. The hemodynamic indices AT and TTP of high-grade tumors were significantly shorter than those of low-grade tumors (p = 0.001, 0.002). In addition, high-grade peripheral zone (PZ) tumors had higher PI than low-grade PZ tumors (p = 0.009). The PZ prostate cancer Gleason score correlated with PI, AT and TTP, with Spearman correlation coefficients of 0.223, -0.335, and -0.351, respectively (p = 0.013, < 0.001 and < 0.001).
Contrast-enhanced ultrasound measurements of hemodynamic indices correlate with the prostate cancer Gleason score.
探讨超声造影能量图能否用于预测前列腺癌的侵袭性。
对 103 例疑诊前列腺癌患者行超声造影检查，对系统穿刺活检部位及超声异常区域进行造影时间-强度曲线分析，获得到达时间（AT）、达峰时间（TTP）、峰值强度（PI）等血流动力学参数，并分析其在高级别和低级别前列腺癌之间的差异，以及与前列腺穿刺活检 Gleason 评分的相关性。
103 例患者中，41 例经前列腺穿刺活检证实为前列腺癌，其中前列腺癌组和非癌组穿刺活检部位的血流动力学参数比较，差异有统计学意义（p < 0.05）。前列腺穿刺活检共检出 154 个前列腺癌病灶，其中低级别前列腺癌 31 个，高级别前列腺癌 123 个。高级别肿瘤的 AT、TTP 显著短于低级别肿瘤（p = 0.001、0.002），且高级别外周带肿瘤的 PI 显著高于低级别外周带肿瘤（p = 0.009）。前列腺外周带癌的 Gleason 评分与 PI、AT、TTP 均呈正相关，Spearman 相关系数分别为 0.223、-0.335、-0.351（p = 0.013、< 0.001、< 0.001）。
超声造影能量图参数与前列腺癌 Gleason 评分具有相关性。
