Applegate Catherine C, Lowerison Matthew R, Hambley Emma, Song Pengfei, Wallig Matthew A, Erdman John W
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Sci Rep. 2021 Sep 17;11(1):18548. doi: 10.1038/s41598-021-97539-2.
Prostate cancer (PCa) remains the second most diagnosed cancer worldwide. Higher body weight is associated with chronic inflammation, increased angiogenesis, and treatment-resistant tumor phenotypes. Dietary tomato reduces PCa risk, which may be due to tomato inhibition of angiogenesis and disruption of androgen signaling. This pilot study investigated the interplay between tomato powder (TP), incorporated into control (CON) and obesogenic (OB) diets, and PCa tumor growth and blood perfusion over time in a transgenic model of PCa (TRAMP). Ultrasound microvessel imaging (UMI) results showed good agreement with gold-standard immunohistochemistry quantification of endothelial cell density, indicating that this technique can be applied to non-invasively monitor tumor blood perfusion in vivo. Greater body weight was positively associated with tumor growth. We also found that TP significantly inhibited prostate tumor angiogenesis but that this inhibition differentially affected measured outcomes depending on CON or OB diets. TP led to reduced tumor growth, intratumoral inflammation, and intratumoral androgen-regulated gene expression (srd5a1, srd5a2) when incorporated with the CON diet but greater tumor growth and intratumoral gene expression when incorporated with the OB diet. Results from this study show that protective benefits from dietary tomato are lost, or may become deleterious, when combined with a Western-style diet.
前列腺癌（PCa）仍然是全球第二大最常被诊断出的癌症。较高的体重与慢性炎症、血管生成增加以及抗治疗的肿瘤表型有关。食用番茄可降低患前列腺癌的风险，这可能是由于番茄抑制血管生成以及破坏雄激素信号传导。这项初步研究调查了添加到对照（CON）饮食和致肥胖（OB）饮食中的番茄粉（TP）与前列腺癌转基因模型（TRAMP）中前列腺癌肿瘤生长和血液灌注随时间的相互作用。超声微血管成像（UMI）结果与内皮细胞密度的金标准免疫组织化学定量结果显示出良好的一致性，表明该技术可用于在体内非侵入性监测肿瘤血液灌注。体重增加与肿瘤生长呈正相关。我们还发现，TP显著抑制前列腺肿瘤血管生成，但这种抑制对测量结果的影响因CON或OB饮食而异。当与CON饮食一起使用时，TP导致肿瘤生长减少、肿瘤内炎症减轻以及肿瘤内雄激素调节基因表达（srd5a1、srd5a2）降低，但当与OB饮食一起使用时，肿瘤生长和肿瘤内基因表达增加。这项研究的结果表明，当与西式饮食结合时，食用番茄的保护益处会丧失，或者可能变得有害。
