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本文引用的文献

1
EGFR antagonists in cancer treatment.癌症治疗中的表皮生长因子受体拮抗剂
N Engl J Med. 2008 Mar 13;358(11):1160-74. doi: 10.1056/NEJMra0707704.
2
Biological activity in vitro of anti-epidermal growth factor receptor monoclonal antibodies with different affinities.不同亲和力的抗表皮生长因子受体单克隆抗体的体外生物学活性
Hybridoma (Larchmt). 2007 Dec;26(6):423-31. doi: 10.1089/hyb.2007.0516.
3
Systemic and skin toxicity in Cercopithecus aethiops sabaeus monkeys treated during 26 weeks with a high intravenous dose of the anti- epidermal growth factor receptor monoclonal antibody Nimotuzumab.用高静脉剂量的抗表皮生长因子受体单克隆抗体尼妥珠单抗对埃塞俄比亚长尾猴进行26周治疗后的全身和皮肤毒性。
Cancer Biol Ther. 2007 Sep;6(9):1390-5. doi: 10.4161/cbt.6.9.4539. Epub 2007 Jun 5.
4
Incidence and management of cutaneous toxicities associated with cetuximab.西妥昔单抗相关皮肤毒性的发生率及管理
Expert Opin Drug Saf. 2007 Mar;6(2):175-82. doi: 10.1517/14740338.6.2.175.
5
Panitumumab the first fully human monoclonal antibody: from the bench to the clinic.帕尼单抗——首个完全人源化单克隆抗体：从实验室到临床应用
Anticancer Drugs. 2007 Jan;18(1):7-15. doi: 10.1097/CAD.0b013e32800feecb.
6
Dermatologic side effects associated with the epidermal growth factor receptor inhibitors.与表皮生长因子受体抑制剂相关的皮肤副作用。
J Am Acad Dermatol. 2006 Oct;55(4):657-70. doi: 10.1016/j.jaad.2005.10.010.
7
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck.放疗联合西妥昔单抗治疗头颈部鳞状细胞癌。
N Engl J Med. 2006 Feb 9;354(6):567-78. doi: 10.1056/NEJMoa053422.
8
Nimotuzumab: evidence of clinical benefit without rash.尼妥珠单抗：无皮疹的临床获益证据。
Oncologist. 2005 Oct;10(9):760-1. doi: 10.1634/theoncologist.10-9-760.
9
Recent developments related to the EGFR as a target for cancer chemotherapy.表皮生长因子受体作为癌症化疗靶点的相关最新进展。
Curr Opin Pharmacol. 2005 Aug;5(4):343-9. doi: 10.1016/j.coph.2005.02.007.
10
ERBB receptors and cancer: the complexity of targeted inhibitors.ERBB受体与癌症：靶向抑制剂的复杂性
Nat Rev Cancer. 2005 May;5(5):341-54. doi: 10.1038/nrc1609.

尼妥珠单抗，一种有前景的治疗上皮来源肿瘤的治疗性单克隆抗体。

Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin.

机构信息

Biocon Limited, Bangalore, India.

出版信息

MAbs. 2009 Jan-Feb;1(1):41-8. doi: 10.4161/mabs.1.1.7509.

DOI:10.4161/mabs.1.1.7509
PMID:20046573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2715181/
Abstract

Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor (EGFR). Clinical trials are ongoing globally to evaluate nimotuzumab in different indications. Nimotuzumab has been granted approval for use in squamous cell carcinoma of head and neck (SCCHN), glioma and nasopharyngeal cancer in different countries. This review focuses on the unique functional characteristics of nimotuzumab. Also, it discusses the safety and efficacy data obtained from the Phase IIb clinical trial conducted in India in SCCHN. Post marketing surveillance data from Cuba for the use of nimotuzumab in pediatric and adult glioma is also discussed. Overall, nimotuzumab has immense therapeutic potential in cancers of epithelial origin.

摘要

尼妥珠单抗是一种针对表皮生长因子受体（EGFR）的人源化治疗性单克隆抗体。目前正在全球范围内开展临床试验，以评估尼妥珠单抗在不同适应症中的疗效。尼妥珠单抗已在多个国家获得批准，可用于治疗头颈部鳞状细胞癌（SCCHN）、脑胶质瘤和鼻咽癌。本文重点介绍了尼妥珠单抗的独特功能特性，并讨论了在印度开展的针对 SCCHN 的 IIb 期临床试验中获得的安全性和疗效数据。还讨论了古巴开展的针对儿童和成人脑胶质瘤使用尼妥珠单抗的上市后监测数据。总的来说，尼妥珠单抗在上皮来源的癌症中具有巨大的治疗潜力。