Sontas Hasan B, Dokuzeylu Banu, Turna Ozge, Ekici Hayri
Departments of Obstetrics and Gynecology, Istanbul University, Avcilar, Turkey.
Can Vet J. 2009 Oct;50(10):1054-8.
Exogenous estrogens used for therapeutic purposes or endogenous estrogen sources such as functional Sertoli cell or ovarian granulosa cell tumors may cause bone marrow toxicity in dogs. The condition is characterized by hematologic abnormalities including thrombocytopenia, anemia, and leukocytosis or leukopenia. Despite intensive therapy with blood or platelet-rich transfusions, broad-spectrum antibiotics, steroids, and bone marrow stimulants, prognosis is unfavorable. Due to the the risk of stimulating the development of uterine diseases and the potential for inducing aplastic anemia, estrogen use in dogs is best avoided where possible. This paper describes the causes of estrogen-induced myelotoxicity, the clinical presentation of the patients, the diagnosis, and the treatment options in the dog.
用于治疗目的的外源性雌激素或内源性雌激素来源，如功能性支持细胞或卵巢颗粒细胞瘤，可能会导致犬类骨髓毒性。该病症的特征是血液学异常，包括血小板减少、贫血以及白细胞增多或白细胞减少。尽管采用了输血或富含血小板的输血、广谱抗生素、类固醇和骨髓刺激剂进行强化治疗，但预后不佳。由于存在刺激子宫疾病发展的风险以及诱发再生障碍性贫血的可能性，因此应尽可能避免在犬类中使用雌激素。本文描述了犬类雌激素诱导的骨髓毒性的病因、患者的临床表现、诊断方法以及治疗选择。
