Dwibhashyam V S N M, Nagappa A N
Pharmacy Practice Department, 4th Floor, Shirdi Sai Baba Cancer Hospital, Manipal-576 104, India.
Indian J Pharm Sci. 2008 Mar-Apr;70(2):145-53. doi: 10.4103/0250-474X.41446.
Treating central nervous system diseases is very challenging because of the presence of a variety of formidable obstacles that impede drug delivery. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very difficult. The present review provides a brief account of the blood brain barrier, the P-glycoprotein efflux and various strategies for enhancing drug delivery to the central nervous system.
由于存在各种阻碍药物递送的巨大障碍，治疗中枢神经系统疾病极具挑战性。血脑屏障和血脑脊液屏障等生理屏障以及各种外排转运蛋白使得药物进入中枢神经系统非常困难。本综述简要介绍了血脑屏障、P-糖蛋白外排以及增强药物向中枢神经系统递送的各种策略。
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