Wahid A, Sridhar B K, Shivakumar S
Department of Pharmaceutics. National College of Pharmacy, Shimoga-577 201, India.
Indian J Pharm Sci. 2008 Jul-Aug;70(4):455-60. doi: 10.4103/0250-474X.44593.
In the present investigation chitosan has been chemically modified by treating with two different aldehydes like acetaldehyde and propionaldehyde to form Schiff's bases. Schiff's bases of chitosan with acetaldehyde and propionaldehyde were named as polymer A and polymer B, respectively. Fourier Transform Infra Red (FTIR) spectral data have confirmed the reaction carried out on chitosan. Drug free polymeric films of chitosan, chemically modified chitosan and chitosan/hydroxypropylmethylcellulose blend were prepared and evaluated for various physicochemical characters. Further, the films were incorporated with anti-inflammatory drug, etoricoxib using glycerol as plasticizer. The drug loaded films were cross-linked with sodium citrate and studied for permeation characteristics across dialysis membrane and rat skin. All the films were evaluated for bursting strength, swelling index, moisture uptake, thickness uniformity, drug content uniformity, tensile strength, percent elongation at break, percent flatness, water vapour transmission rate and in vitro drug permeation study.
在本研究中，壳聚糖通过用两种不同的醛（如乙醛和丙醛）处理进行化学改性，以形成席夫碱。壳聚糖与乙醛和丙醛形成的席夫碱分别命名为聚合物A和聚合物B。傅里叶变换红外（FTIR）光谱数据证实了在壳聚糖上进行的反应。制备了壳聚糖、化学改性壳聚糖和壳聚糖/羟丙基甲基纤维素共混物的无药聚合物薄膜，并对其各种物理化学性质进行了评估。此外，使用甘油作为增塑剂，将抗炎药物依托考昔掺入薄膜中。载药薄膜用柠檬酸钠交联，并研究其在透析膜和大鼠皮肤上的渗透特性。对所有薄膜进行了破裂强度、溶胀指数、吸湿率、厚度均匀性、药物含量均匀性、拉伸强度、断裂伸长率、平整度百分比、水蒸气透过率和体外药物渗透研究。
