Kadam A U, Sakarkar D M, Kawtikwar P S
S. N. Institute of Pharmacy, Pusad, Dist. Yavatmal-445 204, India.
Indian J Pharm Sci. 2008 Jul-Aug;70(4):531-4. doi: 10.4103/0250-474X.44613.
An oral controlled release suspension of chlorpheniramine maleate was prepared using ion-exchange resin technology. A strong cation exchange resin Indion 244 was utilized for the sorption of the drug and the drug resinates was evaluated for various physical and chemical parameters. The drug-resinate complex was microencapsulated with a polymer Eudragit RS 100 to further retard the release characteristics. Both the drug-resinate complex and microencapsulated drug resinate were suspended in a palatable aqueous suspension base and were evaluated for controlled release characteristic. Stability study indicated that elevated temperature did not alter the sustained release nature of the dosage form indicating that polymer membrane surrounding the core material remained intact throughout the storage period.
采用离子交换树脂技术制备了马来酸氯苯那敏口服控释混悬剂。使用强阳离子交换树脂Indion 244吸附药物，并对药物树脂酸盐的各种物理和化学参数进行了评估。用聚合物Eudragit RS 100对药物-树脂酸盐复合物进行微囊化，以进一步延缓释放特性。将药物-树脂酸盐复合物和微囊化药物树脂酸盐都悬浮在可口的水性混悬剂基质中，并对其控释特性进行了评估。稳定性研究表明，高温并未改变剂型的缓释性质，这表明在整个储存期间，包裹核心材料的聚合物膜保持完整。
