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[阿普加压素、奥西丹、地普嗪、腺苷、烟酰胺腺嘌呤二核苷酸和烟酰胺组合对大鼠抗缺氧能力及碳水化合物代谢指标的影响]

[Effect of combinations of apressin, obsidan, diprazin, adenosine, NAD and nicotinamide on the resistance of rats to hypoxia and on carbohydrate metabolic indices].

作者信息

Abakumov G Z

出版信息

Farmakol Toksikol. 1977 Sep-Oct;40(5):620-3.

PMID:200468
Abstract

As evidenced from experiments on rats, a combined application of apressin with obsidan and diprazine, and also of adenozine with nicotine-amidadenine-dinucleotide (NAD), as well as of adeozine with nicotine amide potentiates the protective effect of these substances in hypobaric hypoxia, increases the resistance of the animals to cerebral ischemia, brings down the excess lactate level and raises the redoz potential of the system lactic-acid-pyruvic acid in the brain of rats exposed to the effects of rarefied atmosphere.

摘要

从对大鼠的实验可以看出,加压素与奥西丹和地普嗪联合应用,腺苷与烟酰胺腺嘌呤二核苷酸(NAD)联合应用,以及腺苷与烟酰胺联合应用,可增强这些物质在低压缺氧中的保护作用,提高动物对脑缺血的耐受性,降低过高的乳酸水平,并提高暴露于稀薄大气影响下的大鼠大脑中乳酸 - 丙酮酸系统的氧化还原电位。

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