[Effect of nicotinamide, adenosine and nicotinamide-adenine dinucleotide on the NAD and NAD.H2 content in the liver and brain of intact rats and in hypoxia].

Nicotine-amide (25 mg/kg) in the liver and adenosine (50 mg/kg) in the liver and brain of intact rats enhance the NAD+NAD'H2 content. These drugs when used in the same doses raise the NAD+NAD'H2 level in the organs reduced in hypoxia and their proportion only with the combined application of these drugs. NAD (30 mg/kg) increases the NAD+NAD'H2 concentration in the liver and brain of intact and in the liver of "hypoxic" rats. It appears that in the mechanism of the antihypoxic action of nicotine-amide, adenozine and NAD a definite part plays their action on the level of nicotine-amide co-enzymes.