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1
Erratum: Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model.
J Ocul Biol Dis Infor. 2009 Sep;2(3):127-136. doi: 10.1007/s12177-009-9035-5. Epub 2009 Sep 16.
2
Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model.枸杞对大鼠高眼压模型中视网膜神经节细胞存活的小胶质细胞调节作用。
J Ocul Biol Dis Infor. 2009 Jun;2(2):47-56. doi: 10.1007/s12177-009-9023-9. Epub 2009 Jul 1.
3
Up-regulation of crystallins is involved in the neuroprotective effect of wolfberry on survival of retinal ganglion cells in rat ocular hypertension model.枸杞上调晶体蛋白参与枸杞对高眼压大鼠视网膜神经节细胞存活的神经保护作用。
J Cell Biochem. 2010 May 15;110(2):311-20. doi: 10.1002/jcb.22539.
4
Effect of Lycium barbarum (Wolfberry) on alleviating axonal degeneration after partial optic nerve transection.枸杞对减轻部分视神经横断后轴突退变的作用。
Cell Transplant. 2015;24(3):403-17. doi: 10.3727/096368915X686896. Epub 2015 Jan 23.
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(Wolfberry) Increases Retinal Ganglion Cell Survival and Affects both Microglia/Macrophage Polarization and Autophagy after Rat Partial Optic Nerve Transection.（枸杞）增加大鼠部分视神经横断后视网膜神经节细胞的存活，并影响小胶质细胞/巨噬细胞的极化和自噬。
Cell Transplant. 2019 May;28(5):607-618. doi: 10.1177/0963689719835181. Epub 2019 Mar 6.
6
Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma.枸杞多糖对大鼠青光眼高眼压模型中内皮素-1及其受体表达的影响
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Lycium barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection.枸杞（宁夏枸杞）可减少部分视神经切断后视网膜的继发性变性和氧化应激，并抑制 JNK 通路。
PLoS One. 2013 Jul 19;8(7):e68881. doi: 10.1371/journal.pone.0068881. Print 2013.
8
Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation.抗血管内皮生长因子作用于眼部炎症大鼠模型中的视网膜小胶质细胞/巨噬细胞激活。
Mol Vis. 2014 Jun 23;20:908-20. eCollection 2014.
9
Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage.枸杞多糖通过激活 Nrf2/HO-1 抗氧化通路对缺血再灌注损伤诱导的啮齿动物视网膜损伤发挥保护作用。
PLoS One. 2014 Jan 6;9(1):e84800. doi: 10.1371/journal.pone.0084800. eCollection 2014.
10
Carbon monoxide treatment reduces microglial activation in the ischemic rat retina.一氧化碳治疗可减轻缺血性大鼠视网膜中的小胶质细胞活化。
Graefes Arch Clin Exp Ophthalmol. 2016 Oct;254(10):1967-1976. doi: 10.1007/s00417-016-3435-6. Epub 2016 Jul 21.

引用本文的文献

1
Effect of the Notch signaling pathway on retinal ganglion cells and its neuroprotection in rats with acute ocular hypertension.Notch信号通路对急性高眼压大鼠视网膜神经节细胞的影响及其神经保护作用
Int J Ophthalmol. 2018 Feb 18;11(2):208-215. doi: 10.18240/ijo.2018.02.05. eCollection 2018.
2
Rational Basis for Nutraceuticals in the Treatment of Glaucoma.营养保健品治疗青光眼的合理基础。
Curr Neuropharmacol. 2018;16(7):1004-1017. doi: 10.2174/1570159X15666171109124520.
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Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury.枸杞多糖可保护大鼠肝脏免受非酒精性脂肪性肝炎损伤。
Nutr Diabetes. 2013 Jul 22;3(7):e81. doi: 10.1038/nutd.2013.22.

本文引用的文献

1
Retrograde labeling of retinal ganglion cells by application of fluoro-gold on the surface of superior colliculus.通过将荧光金应用于上丘表面对视网膜神经节细胞进行逆行标记。
J Vis Exp. 2008 Jun 17(16):819. doi: 10.3791/819.
2
Intravitreous injection for establishing ocular diseases model.玻璃体腔内注射用于建立眼部疾病模型。
J Vis Exp. 2007(8):313. doi: 10.3791/313. Epub 2007 Oct 1.
3
Laser-induced chronic ocular hypertension model on SD rats.SD大鼠激光诱导慢性高眼压模型
J Vis Exp. 2007(10):549. doi: 10.3791/549. Epub 2007 Dec 4.
4
Microglia: active sensor and versatile effector cells in the normal and pathologic brain.小胶质细胞：正常和病理状态下大脑中的活跃传感器及多功能效应细胞
Nat Neurosci. 2007 Nov;10(11):1387-94. doi: 10.1038/nn1997.
5
Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?抗衰老草药枸杞用于对抗与衰老相关疾病。我们目前了解到什么？
Cell Mol Neurobiol. 2008 Aug;28(5):643-52. doi: 10.1007/s10571-007-9181-x. Epub 2007 Aug 21.
6
Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model.在小鼠阿尔茨海默病模型中，选择性清除骨髓来源的树突状细胞会增加淀粉样斑块。
Eur J Neurosci. 2007 Jul;26(2):413-6. doi: 10.1111/j.1460-9568.2007.05652.x. Epub 2007 Jul 10.
7
Characterization of the effects of anti-aging medicine Fructus lycii on beta-amyloid peptide neurotoxicity.抗衰老药物枸杞子对β-淀粉样肽神经毒性作用的表征
Int J Mol Med. 2007 Aug;20(2):261-8.
8
The function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro.小胶质细胞的功能，无论是神经保护还是神经毒性，都由体外活化小胶质细胞释放的各种因子之间的平衡所决定。
Brain Res. 2007 Jul 23;1159:8-17. doi: 10.1016/j.brainres.2007.04.066. Epub 2007 May 3.
9
Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on beta-amyloid peptide neurotoxicity.表征枸杞碱性提取物对β-淀粉样肽神经毒性的神经保护作用。
Brain Res. 2007 Jul 16;1158:123-34. doi: 10.1016/j.brainres.2007.04.075. Epub 2007 May 6.
10
Lycium barbarum polysaccharides regulate phenotypic and functional maturation of murine dendritic cells.枸杞多糖调节小鼠树突状细胞的表型和功能成熟。
Cell Biol Int. 2007 Jun;31(6):615-9. doi: 10.1016/j.cellbi.2006.12.002. Epub 2006 Dec 30.

Erratum: Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model.

作者信息

Chiu Kin, Chan Hiu-Chi, Yeung Sze-Chun, Yuen Wai-Hung, Zee Sze-Yong, Chang Raymond Chuen-Chung, So Kwok-Fai

出版信息

J Ocul Biol Dis Infor. 2009 Sep;2(3):127-136. doi: 10.1007/s12177-009-9035-5. Epub 2009 Sep 16.

DOI:10.1007/s12177-009-9035-5
PMID:20046845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2798983/
Abstract

The active component of Wolfberry (Lycium barbarum), lycium barbarum polysaccharides (LBP), has been shown to be neuroprotective to retinal ganglion cells (RGCs) against ocular hypertension (OH). Aiming to study whether this neuroprotection is mediated via modulating immune cells in the retina, we used multiphoton confocal microscopy to investigate morphological changes of microglia in whole-mounted retinas. Retinas under OH displayed slightly activated microglia. One to 100 mg/kg LBP exerted the best neuroprotection and elicited moderately activated microglia in the inner retina with ramified appearance but thicker and focally enlarged processes. Intravitreous injection of bacterial endotoxin lipopolysaccharide (LPS) decreased the survival of RGCs at 4 weeks, and the activated microglia exhibited amoeboid appearance as fully activated phenotype. When activation of microglia was attenuated by intravitreous injection of macrophage/microglia inhibitory factor, protective effect of 10 mg/kg LBP was attenuated. The results implicated that neuroprotective effects of LBP were partly due to modulating the activation of microglia.[This corrects the article on p. in vol. .].

摘要