Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors.
作者信息
Horti Andrew G, Wong Dean F
出版信息
PET Clin. 2009 Jan 1;4(1):89-100. doi: 10.1016/j.cpet.2009.04.014.
Abstract
摘要
相似文献
1
Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors.用于脑烟碱型乙酰胆碱受体成像的PET放射性配体的临床视角与最新进展
PET Clin. 2009 Jan 1;4(1):89-100. doi: 10.1016/j.cpet.2009.04.014.
2
Recent PET radioligands with optimal brain kinetics for imaging nicotinic acetylcholine receptors.近期具有用于成像烟碱型乙酰胆碱受体的最佳脑动力学的PET放射性配体。
J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):159-66. doi: 10.1002/jlcr.3020.
3
Development of radioligands with optimized imaging properties for quantification of nicotinic acetylcholine receptors by positron emission tomography.通过正电子发射断层扫描技术开发具有优化成像特性的放射性配体，用于定量检测烟碱型乙酰胆碱受体。
Life Sci. 2010 Apr 10;86(15-16):575-84. doi: 10.1016/j.lfs.2009.02.029. Epub 2009 Mar 18.
4
Neural nAChRs PET imaging probes.神经烟碱乙酰胆碱受体正电子发射断层显像探针
Nucl Med Commun. 2014 Feb;35(2):135-43. doi: 10.1097/MNM.0000000000000032.
5
Recent development of radioligands for imaging α7 nicotinic acetylcholine receptors in the brain.脑内α7 烟碱型乙酰胆碱受体显像剂的研究进展。
Curr Top Med Chem. 2010;10(15):1544-57. doi: 10.2174/156802610793176828.
6
Advances in PET Imaging of α7 Nicotinic Receptors: From Radioligand Development to CNS Applications.α7烟碱型受体的正电子发射断层扫描成像进展：从放射性配体开发到中枢神经系统应用
Basic Clin Pharmacol Toxicol. 2025 Apr;136(4):e70025. doi: 10.1111/bcpt.70025.
7
PET Imaging of nicotinic acetylcholine receptors in baboons with 18F-AZAN, a radioligand with improved brain kinetics.利用具有改善脑内动力学特性的放射性配体 18F-AZAN 对狒狒进行烟碱型乙酰胆碱受体 PET 成像。
J Nucl Med. 2012 Jan;53(1):121-9. doi: 10.2967/jnumed.111.092338. Epub 2011 Dec 15.
8
PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders.正电子发射断层扫描成像在神经退行性疾病中胆碱能神经传递的应用。
J Nucl Med. 2022 Jun;63(Suppl 1):33S-44S. doi: 10.2967/jnumed.121.263198.
9
The quest for Eldorado: development of radioligands for in vivo imaging of nicotinic acetylcholine receptors in human brain.寻找黄金国：用于人脑烟碱型乙酰胆碱受体体内成像的放射性配体的研发
Curr Pharm Des. 2006;12(30):3877-900. doi: 10.2174/138161206778559605.
10
Development of radioligands for the imaging of α7 nicotinic acetylcholine receptors with positron emission tomography.正电子发射断层扫描成像用α7 烟碱型乙酰胆碱受体放射性配体的研制。
Curr Drug Targets. 2012 May;13(5):594-601. doi: 10.2174/138945012800398955.
引用本文的文献
1
F-XTRA PET for Enhanced Imaging of the Extrathalamic α4β2 Nicotinic Acetylcholine Receptor.F-XTRA PET 用于增强脑外 α4β2 型烟碱型乙酰胆碱受体显像
J Nucl Med. 2018 Oct;59(10):1603-1608. doi: 10.2967/jnumed.117.205492. Epub 2018 Mar 1.
2
Imaging α4β2 Nicotinic Acetylcholine Receptors (nAChRs) in Baboons with [F]XTRA, a Radioligand with Improved Specific Binding in Extra-Thalamic Regions.使用[F]XTRA（一种在丘脑外区域具有改善的特异性结合的放射性配体）对狒狒中的α4β2烟碱型乙酰胆碱受体（nAChRs）进行成像。
Mol Imaging Biol. 2017 Apr;19(2):280-288. doi: 10.1007/s11307-016-0999-9.
3
Development of [(18)F]ASEM, a specific radiotracer for quantification of the α7-nAChR with positron-emission tomography.[18F]ASEM的研发，一种用于通过正电子发射断层扫描定量α7烟碱型乙酰胆碱受体的特异性放射性示踪剂。
Biochem Pharmacol. 2015 Oct 15;97(4):566-575. doi: 10.1016/j.bcp.2015.07.030. Epub 2015 Jul 29.
4
Imaging in sepsis-associated encephalopathy--insights and opportunities.脓毒症相关性脑病的影像学——见解与机遇。
Nat Rev Neurol. 2013 Oct;9(10):551-61. doi: 10.1038/nrneurol.2013.177. Epub 2013 Sep 3.
5
Synthesis and evaluation of new radioligands [(11)C]A-833834 and [(11)C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors.新型放射性配体 [(11)C]A-833834 和 [(11)C]A-752274 的合成与评价及其用于α7-烟碱型乙酰胆碱受体的正电子发射断层扫描显像。
Nucl Med Biol. 2013 Apr;40(3):395-402. doi: 10.1016/j.nucmedbio.2012.11.013. Epub 2013 Jan 5.
6
5-(5-(6-[(11)C]methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)pyridin-2-yl)-1H-indole as a potential PET radioligand for imaging cerebral α7-nAChR in mice.5-(5-(6-[(11)C]甲基-3,6-二氮杂双环[3.2.0]庚烷-3-基)吡啶-2-基)-1H-吲哚作为一种潜在的用于在小鼠中成像脑 α7-nAChR 的 PET 放射性配体。
Bioorg Med Chem. 2012 Jun 15;20(12):3698-702. doi: 10.1016/j.bmc.2012.04.056. Epub 2012 May 4.
7
Imaging radiation-induced normal tissue injury.影像学诊断辐射导致的正常组织损伤。
Radiat Res. 2012 Apr;177(4):449-66. doi: 10.1667/rr2530.1. Epub 2012 Feb 21.
8
Positron emission tomography experience with 2-[¹⁸F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[¹⁸F]FA) in the living human brain of smokers with paranoid schizophrenia.正电子发射断层扫描技术在吸烟的偏执型精神分裂症患者活体大脑中 2-[¹⁸F]氟-3-(2(S)-氮杂环丁烷甲氧基)吡啶（2-[¹⁸F]FA）的应用经验。
Synapse. 2012 Apr;66(4):352-68. doi: 10.1002/syn.21520. Epub 2011 Dec 29.
本文引用的文献
1
Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography.新型碳-11标记吡啶醚的合成与生物学评价：用于正电子发射断层扫描体内成像大脑中α4β2烟碱型乙酰胆碱受体（α4β2-nAChRs）的候选配体
Bioorg Med Chem. 2009 Jul 1;17(13):4367-77. doi: 10.1016/j.bmc.2009.05.021. Epub 2009 May 15.
2
3
Galantamine-induced improvements in cognitive function are not related to alterations in alpha(4)beta (2) nicotinic receptors in early Alzheimer's disease as measured in vivo by 2-[18F]fluoro-A-85380 PET.加兰他敏诱导的认知功能改善与早期阿尔茨海默病中α(4)β(2)烟碱型受体的改变无关，这是通过2-[18F]氟-A-85380正电子发射断层扫描（PET）在体内测量得出的。
Psychopharmacology (Berl). 2009 Jan;202(1-3):79-91. doi: 10.1007/s00213-008-1347-9. Epub 2008 Oct 24.
4
New synthesis and evaluation of enantiomers of 7-methyl-2-exo-(3'-iodo-5'-pyridinyl)-7-azabicyclo[2.2.1]heptane as stereoselective ligands for PET imaging of nicotinic acetylcholine receptors.7-甲基-2-外型-(3'-碘-5'-吡啶基)-7-氮杂双环[2.2.1]庚烷对映体的新合成及评价：作为烟碱型乙酰胆碱受体PET成像的立体选择性配体
Bioorg Med Chem Lett. 2008 Dec 1;18(23):6168-70. doi: 10.1016/j.bmcl.2008.10.012. Epub 2008 Oct 7.
5
Relationship between nicotinic receptors and cognitive function in early Alzheimer's disease: a 2-[18F]fluoro-A-85380 PET study.早期阿尔茨海默病中烟碱受体与认知功能的关系：一项2-[18F]氟-A-85380正电子发射断层显像研究
Neurobiol Learn Mem. 2008 Sep;90(2):404-12. doi: 10.1016/j.nlm.2008.05.006. Epub 2008 Jul 11.
6
Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties.(-)-7-甲基-2-外向型-[3'-(6-[¹⁸F]氟吡啶-2-基)-5'-吡啶基]-7-氮杂双环[2.2.1]庚烷的发现，一种用于脑烟碱型乙酰胆碱受体（α4β2-nAChR）的具有最佳正电子发射断层扫描成像特性的放射性标记拮抗剂。
J Med Chem. 2008 Aug 14;51(15):4751-64. doi: 10.1021/jm800323d. Epub 2008 Jul 8.
7
Acetylcholine receptors in dementia and mild cognitive impairment.痴呆症和轻度认知障碍中的乙酰胆碱受体
Eur J Nucl Med Mol Imaging. 2008 Mar;35 Suppl 1:S30-45. doi: 10.1007/s00259-007-0701-1.
8
In vivo measurement of nicotinic acetylcholine receptors with [18F]norchloro-fluoro-homoepibatidine.使用[18F]去氯氟高表鬼臼毒素在体内测量烟碱型乙酰胆碱受体。
Synapse. 2008 Mar;62(3):205-18. doi: 10.1002/syn.20480.
9
Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain.吸烟会上调人脑中的α4β2*烟碱型乙酰胆碱受体。
Neurosci Lett. 2008 Jan 3;430(1):34-7. doi: 10.1016/j.neulet.2007.10.011. Epub 2007 Oct 22.
10
NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation.NIDA522131，一种用于成像丘脑外烟碱型乙酰胆碱受体的新型放射性配体：体外和体内评估。
J Neurochem. 2008 Jan;104(2):306-15. doi: 10.1111/j.1471-4159.2007.05009.x. Epub 2007 Nov 6.
Zotero 插件