Kinghorn A Douglas, Carcache de Blanco Esperanza J, Chai Hee-Byung, Orjala Jimmy, Farnsworth Norman R, Soejarto D Doel, Oberlies Nicholas H, Wani Mansukh C, Kroll David J, Pearce Cedric J, Swanson Steven M, Kramer Robert A, Rose William C, Fairchild Craig R, Vite Gregory D, Emanuel Stuart, Jarjoura David, Cope Frederick O
College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Pure Appl Chem. 2009 Jan 1;81(6):1051-1063. doi: 10.1351/PAC-CON-08-10-16.
A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.
本文描述了一个多学科合作的研究项目，该项目从热带植物、水生蓝细菌和丝状真菌等多种生物中获取新的天然产物抗癌药物先导物。文中介绍了这些生物的采集和处理方式，并指出了对这些采集物的粗提物进行测试的生物测定类型。此外，还讨论了从三种热带植物中分离具有生物活性的先导次生代谢物所取得的进展。
