Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , The Ohio State University , Columbus , Ohio 43210 , United States.
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60612 , United States.
J Nat Prod. 2019 Mar 22;82(3):657-679. doi: 10.1021/acs.jnatprod.9b00018. Epub 2019 Mar 4.
Higher plants are well known for their value in affording clinically useful anticancer agents, with such compounds acting against cancer cells by a range of mechanisms of action. There remains a strong interest in the discovery and development of plant secondary metabolites as additional cancer chemotherapeutic lead compounds. In the present review, progress on the discovery of plant-derived compounds of the biflavonoid, lignan, sesquiterpene, steroid, and xanthone structural types is presented. Several potential anticancer leads of these types have been characterized from tropical plants collected in three countries as part of our ongoing collaborative multi-institutional project. Preliminary structure-activity relationships and work on in vivo testing and cellular mechanisms of action are also discussed. In addition, the relevant work reported by other groups on the same compound classes is included herein.
高等植物以提供具有临床应用价值的抗癌药物而闻名，这些化合物通过多种作用机制对抗癌细胞。人们仍然对发现和开发植物次生代谢产物作为额外的癌症化疗先导化合物有着浓厚的兴趣。在本综述中，介绍了双黄酮类、木脂素类、倍半萜类、甾体类和蒽酮类结构类型的植物衍生化合物的发现进展。作为我们正在进行的合作多机构项目的一部分，从三个国家采集的热带植物中已经鉴定出了几种具有潜在抗癌作用的这类化合物。还讨论了初步的结构-活性关系以及体内测试和细胞作用机制的工作。此外，本文还包括了其他小组在同一类化合物上的相关工作。
