Department of Zoology, Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary.
Apoptosis. 2010 Mar;15(3):313-21. doi: 10.1007/s10495-009-0446-3.
Programmed cell death leading to apoptosis is essential for normal development and homeostasis in plants and throughout the animal kingdom. Although there are differences in apoptotic mechanisms between lower animals and vertebrates, crucial biochemical components of the programmed cell death pathways remained remarkably conserved throughout evolution. Despite decades of studies on the neurobiology and development of mollusks, comparatively little is known about the mechanisms of apoptosis in this phylum. In this review, an attempt is made to summarize data obtained on mollusks so far, and to discuss the molecular mechanisms, the functional and ecological significance of apoptosis and the advantages of snail preparations as tools for programmed cell death research. A definitive comparison of the data obtained on mollusks with those obtained on the more widely studied vertebrates, will contribute to the better understanding of the apoptotic process in general and of its evolutionary development.
程序性细胞死亡导致的细胞凋亡对于植物和整个动物界的正常发育和内稳态至关重要。尽管较低等动物和脊椎动物的细胞凋亡机制存在差异，但程序性细胞死亡途径的关键生化成分在进化过程中仍然保持着惊人的保守性。尽管对软体动物的神经生物学和发育进行了数十年的研究，但对于该门动物细胞凋亡的机制却知之甚少。在这篇综述中，试图总结迄今为止在软体动物方面获得的数据，并讨论细胞凋亡的分子机制、功能和生态意义，以及蜗牛制剂作为程序性细胞死亡研究工具的优势。将在软体动物上获得的数据与在更广泛研究的脊椎动物上获得的数据进行明确比较，将有助于更好地理解细胞凋亡过程及其进化发展。
