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整合的mRNA和miRNA转录组分析揭示了（某物）对变态诱导物（幼体牡蛎）的反应。 （注：原文中“the response of to”这里少了个关键内容，不太明确完整意思）

Integrated mRNA and miRNA transcriptomic analysis reveals the response of to the metamorphic inducer (juvenile oysters).

作者信息

Yang Mei-Jie, Song Hao, Shi Pu, Liang Jian, Hu Zhi, Zhou Cong, Hu Peng-Peng, Yu Zheng-Lin, Zhang Tao

机构信息

CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.

Laboratory for Marine Science and Technology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.

出版信息

Comput Struct Biotechnol J. 2022 Dec 30;21:702-715. doi: 10.1016/j.csbj.2022.12.047. eCollection 2023.

DOI:10.1016/j.csbj.2022.12.047
PMID:36659925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9826900/
Abstract

Metamorphosis, as a critical developmental event, controls the population dynamics of most marine invertebrates, especially some carnivorous gastropods that feed on bivalves, whose population dynamics not only affect the maintenance of the ecological balance but also impact the protection of bivalve resources; therefore, the metamorphosis of carnivorous gastropods deserve attention. Here, we investigated the mechanism underlying the response of the carnivorous gastropod to its metamorphic inducer juvenile oysters through integrated analysis of miRNA and mRNA profiles. According to the results, we speculated that the AMPK signaling pathway may be the critical regulator in the response to juvenile oysters in competent larvae. The NF-kB and JAK-STAT signaling pathways that regulated apoptosis were also activated by the metamorphic inducer, which may result in the degeneration of the velum. Additionally, the significant changes in the expression of the SARP-19 precursor gene and protein cibby homolog 1-like gene may indicate that these signaling pathways also regulate growth and development during metamorphosis. This study provides further evidence that juvenile oysters can induce metamorphosis of at the transcriptional level, which expands our understanding of the metamorphosis mechanism in carnivorous gastropods

摘要

变态作为一个关键的发育事件，控制着大多数海洋无脊椎动物的种群动态，尤其是一些以双壳类为食的肉食性腹足类动物，其种群动态不仅影响生态平衡的维持，还影响双壳类资源的保护；因此，肉食性腹足类动物的变态值得关注。在此，我们通过对miRNA和mRNA图谱的综合分析，研究了肉食性腹足类动物对其变态诱导物幼体牡蛎的反应机制。根据结果，我们推测AMPK信号通路可能是有能力的幼虫对幼体牡蛎反应中的关键调节因子。调节细胞凋亡的NF-kB和JAK-STAT信号通路也被变态诱导物激活，这可能导致缘膜退化。此外，SARP-19前体基因和蛋白质cibby同源物1样基因表达的显著变化可能表明这些信号通路也在变态过程中调节生长和发育。本研究进一步证明幼体牡蛎可以在转录水平诱导变态，这扩展了我们对肉食性腹足类动物变态机制的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/1fd82e92966b/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/4bec6cd2b603/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/20e08684022b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/36506f6ca850/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/6b862a693a0f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/a889aa679e72/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/5c10d81087ae/gr5a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/1ddec62ccd81/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/4c900bca3658/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/97bb4ecaf11a/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/1fd82e92966b/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/4bec6cd2b603/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/20e08684022b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/36506f6ca850/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/6b862a693a0f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/a889aa679e72/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/5c10d81087ae/gr5a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/1ddec62ccd81/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/4c900bca3658/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/97bb4ecaf11a/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4751/9826900/1fd82e92966b/gr9.jpg

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