Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Int J Hematol. 2010 Jan;91(1):46-53. doi: 10.1007/s12185-009-0472-5. Epub 2010 Jan 5.
B lymphocyte-induced maturation protein (Blimp-1) is a transcriptional factor, which controls the terminal differentiation of mature B cells to plasma cells. Blimp-1 is also called positive regulatory domain I-binding factor-1 (PRDI-BF1) or PR (PRDI-BF1-RIZ) domain zinc finger protein 1 (PRDM1). Furthermore, Blimp-1 is located in chromosome 6q21-22.1, a region frequently deleted in several tumors including lymphoid malignancies and has been supposed to be a candidate of tumor suppressor gene. Recently, mutational inactivation of Blimp-1 has been identified in a subset of diffuse large B-cell lymphomas of the activated B-cell type. In addition, an important role for Blimp-1 in maintaining the homeostasis of effector T cells is emerging and high expression of Blimp-1beta, a splicing variant of Blimp-1, have been presumed to be associated with poor prognosis in T cell lymphoma although this aspect of the gene needs further investigation. For this reason, we focused on the tumor suppressor function of Blimp-1 on not only B but also T cell malignancies in this review.
B 淋巴细胞诱导成熟蛋白 (Blimp-1) 是一种转录因子，它控制成熟 B 细胞向浆细胞的终末分化。Blimp-1 也被称为阳性调节域 I 结合因子-1 (PRDI-BF1) 或 PR (PRDI-BF1-RIZ) 结构域锌指蛋白 1 (PRDM1)。此外，Blimp-1 位于染色体 6q21-22.1 上，该区域在包括淋巴恶性肿瘤在内的几种肿瘤中经常缺失，并被认为是肿瘤抑制基因的候选物。最近，在激活 B 细胞型弥漫性大 B 细胞淋巴瘤的亚组中发现了 Blimp-1 的突变失活。此外，Blimp-1 在维持效应 T 细胞的稳态方面的重要作用正在显现，Blimp-1 的剪接变体 Blimp-1beta 的高表达被认为与 T 细胞淋巴瘤的预后不良有关，尽管该基因的这一方面需要进一步研究。出于这个原因，我们在这篇综述中重点关注了 Blimp-1 不仅在 B 细胞恶性肿瘤而且在 T 细胞恶性肿瘤中的肿瘤抑制功能。
