Xia Yajuan, Hao Guang, Yang Ying
Inner Mongolia Center for Endemic Disease Control and Research, Huhhot 010031, China.
Wei Sheng Yan Jiu. 2009 Nov;38(6):720-2.
To study on reproductive and immune toxicity of male rats exposed to subacute As2O3.
24 male rats of KM-strain were divided into four groups and were given by gavage deionized water, 2.0, 4.0 and 8.0 mg As/(kg x bw) for 7 days. After the exposure, the rats were killed and the testis, epididymis were collected and analysed.
(1) In comparison with control, testicular and epididymal weights were lower than those of high dose group (P < 0.05), but there were no difference of testicular indexes between exposed group and control. The stained sperm count were lower than those of arsenic exposure group (P > 0.05), and malformation rate of sperm were significant increase in middle- and high-dose group (P < 0.05); (2) Compared to control, the weight and index of immune organ was decrease in middle-and high-dose group, and the spleen weight and index was significantly lower in high-dose group (P < 0.05).
As2O3 can induce reproductive and immunotoxicity in male mice.
研究亚急性三氧化二砷暴露对雄性大鼠生殖和免疫毒性。
将24只KM品系雄性大鼠分为四组，分别经口灌胃给予去离子水、2.0、4.0和8.0mg砷/（kg体重），连续7天。染毒结束后，处死大鼠，取睾丸、附睾进行分析。
（1）与对照组相比，睾丸和附睾重量低于高剂量组（P<0.05），但染毒组与对照组睾丸指数无差异。染色精子计数低于砷暴露组（P>0.05），中、高剂量组精子畸形率显著升高（P<0.05）；（2）与对照组相比，中、高剂量组免疫器官重量和指数降低，高剂量组脾脏重量和指数显著降低（P<0.05）。
三氧化二砷可致雄性小鼠生殖和免疫毒性。
