人类胸腺素β4/6 - 26基因是一个多基因家族的一部分，该家族由位于七条不同染色体上的七个成员组成。

Human thymosin-beta 4/6-26 gene is part of a multigene family composed of seven members located on seven different chromosomes.

作者信息

Clauss I M, Wathelet M G, Szpirer J, Islam M Q, Levan G, Szpirer C, Huez G A

机构信息

Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode-St-Genèse, Belgium.

出版信息

Genomics. 1991 Jan;9(1):174-80. doi: 10.1016/0888-7543(91)90236-8.

DOI:10.1016/0888-7543(91)90236-8

PMID:2004759

Abstract

We have isolated a cDNA encoding the human interferon-inducible gene 6-26, by screening a cDNA library with an oligodeoxynucleotide probe. Its sequence was found to be identical to that of the human thymosin-beta 4 cDNA, which encodes a protein present in most cell types, but whose function is not clear at present. By hybridization of the thymosin-beta 4/6-26 cDNA to the DNA of a panel of human-rodent somatic cell hybrids, we found that at least seven genes homologous to this cDNA are present in the human genome. We localized these genes, some of which might be pseudogenes, to seven distinct chromosomes, namely, chromosomes 1, 2, 4, 9, 11, 20, and X.

摘要

我们通过用寡脱氧核苷酸探针筛选cDNA文库，分离出了编码人干扰素诱导基因6 - 26的cDNA。发现其序列与人胸腺素β4 cDNA的序列相同，后者编码一种存在于大多数细胞类型中的蛋白质，但其功能目前尚不清楚。通过将胸腺素β4 / 6 - 26 cDNA与一组人 - 啮齿动物体细胞杂种的DNA杂交，我们发现人类基因组中存在至少七个与该cDNA同源的基因。我们将这些基因（其中一些可能是假基因）定位到七条不同的染色体上，即染色体1、2、4、9、11、20和X。