Department of Cardiovascular Center, Sakura Hospital, Medical Center, Toho University, Chiba, Japan.
Atherosclerosis. 2010 Jun;210(2):581-4. doi: 10.1016/j.atherosclerosis.2009.12.010. Epub 2009 Dec 16.
LR11, an LDL receptor family member, is expressed in intimal smooth muscle cells. It was found that the soluble form of LR11 (sLR11) is detected in serum, and the circulating sLR11 levels are positively correlated with intima-media thickness of carotid arteries in dyslipidemic subjects. To clarify the significance of serum sLR11, the circulating sLR11 levels in patients with organic coronary stenosis and the contributing risk factors for them were studied. The subjects, 150 patients with symptoms of coronary artery disease, underwent coronary angiographic examination, and were divided into sex- and age-matched two groups; one is organic coronary stenosis group (OCS) and the other is normal coronary group (NC). Serum sLR11 levels were significantly higher in OCS than in NC (4.9+/-2.7 U vs 3.6+/-1.8 U, p<0.05). Multivariate regression analysis showed that circulating sLR11 is independent contributing factor for the OCS, as well as diabetes mellitus and dyslipidemia. Among various coronary risk factors for sLR11 level, HbA1c showed the highest correlation coefficient (p<0.01). These results suggest that the circulating sLR11 might reflect coronary organic stenosis, and that hyperglycemic condition might be promoting factor for expression of LR11 in intimal smooth muscle cells.
LR11 是 LDL 受体家族成员，在血管内膜平滑肌细胞中表达。研究发现，LR11 的可溶性形式（sLR11）存在于血清中，且血脂异常患者血清 sLR11 水平与颈动脉内-中膜厚度呈正相关。为明确血清 sLR11 的意义，研究了有器质性冠状动脉狭窄患者的循环 sLR11 水平及其相关的危险因素。对 150 例有冠心病症状的患者进行了冠状动脉造影检查，根据检查结果将患者分为两组，即有机冠状动脉狭窄组（OCS）和正常冠状动脉组（NC）。OCS 患者血清 sLR11 水平显著高于 NC 患者（4.9+/-2.7 U 比 3.6+/-1.8 U，p<0.05）。多变量回归分析表明，循环 sLR11 是 OCS 的独立危险因素，糖尿病和血脂异常也是其危险因素。在 sLR11 水平的各种冠状动脉危险因素中，HbA1c 的相关系数最高（p<0.01）。这些结果提示，循环 sLR11 可能反映了冠状动脉的器质性狭窄，高血糖状态可能是促进血管内膜平滑肌细胞中 LR11 表达的因素。
