Schmidt Vanessa, Subkhangulova Aygul, Willnow Thomas E
Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Str. 10, 13125, Berlin, Germany.
Berlin Institute of Health, Berlin, Germany.
Cell Mol Life Sci. 2017 Apr;74(8):1475-1483. doi: 10.1007/s00018-016-2410-z. Epub 2016 Nov 10.
Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor dysfunction is the underlying cause of common human malignancies, including Alzheimer's disease, atherosclerosis, and obesity. Here, we discuss the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases.
具有A型重复序列的分选相关受体（SORLA）是一种细胞内分选受体，可将诸如激酶、磷酸酶和信号受体等货物蛋白引导至细胞内的正确位置。SORLA的活性确保细胞和组织的正常功能，而受体功能障碍是包括阿尔茨海默病、动脉粥样硬化和肥胖症在内的常见人类恶性肿瘤的根本原因。在这里，我们讨论了在多种细胞类型中控制SORLA及其货物分选的分子机制，以及该受体的基因缺陷为何会导致毁灭性疾病。
