Applied Medical Engineering, Helmholtz-Institute Aachen, RWTH Aachen University, Germany.
Cardiovasc Intervent Radiol. 2012 Aug;35(4):914-20. doi: 10.1007/s00270-011-0253-4. Epub 2011 Aug 11.
To compare the effectiveness of microwave (MW) ablation with radiofrequency (RF) ablation for treating breast tissue in a nonperfused ex vivo model of healthy bovine udder tissue.
MW ablations were performed at power outputs of 25W, 35W, and 45W using a 915-MHz frequency generator and a 2-cm active tip antenna. RF ablations were performed with a bipolar RF system with 2- and 3-cm active tip electrodes. Tissue temperatures were continuously monitored during ablation.
The mean short-axis diameters of the coagulation zones were 1.34 ± 0.14, 1.45 ± 0.13, and 1.74 ± 0.11 cm for MW ablation at outputs of 25W, 35W, and 45W. For RF ablation, the corresponding values were 1.16 ± 0.09 and 1.26 ± 0.14 cm with electrodes having 2- and 3-cm active tips, respectively. The mean coagulation volumes were 2.27 ± 0.65, 2.85 ± 0.72, and 4.45 ± 0.47 cm(3) for MW ablation at outputs of 25W, 35W, and 45W and 1.18 ± 0.30 and 2.29 ± 0.55 cm(3) got RF ablation with 2- and 3-cm electrodes, respectively. MW ablations at 35W and 45W achieved significantly longer short-axis diameters than RF ablations (P < 0.05). The highest tissue temperature was achieved with MW ablation at 45W (P < 0.05). On histological examination, the extent of the ablation zone in MW ablations was less affected by tissue heterogeneity than that in RF ablations.
MW ablation appears to be advantageous with respect to the volume of ablation and the shape of the margin of necrosis compared with RF ablation in an ex vivo bovine udder.
比较微波 (MW) 消融与射频 (RF) 消融治疗非灌注健康牛乳房组织离体模型中乳房组织的疗效。
使用 915MHz 频率发生器和 2cm 有源尖端天线，MW 消融在 25W、35W 和 45W 的功率输出下进行。RF 消融使用具有 2cm 和 3cm 有源尖端电极的双极 RF 系统进行。在消融过程中连续监测组织温度。
MW 消融在输出功率为 25W、35W 和 45W 时，凝固区的平均短轴直径分别为 1.34 ± 0.14cm、1.45 ± 0.13cm 和 1.74 ± 0.11cm。RF 消融时，使用 2cm 和 3cm 有源尖端电极的相应值分别为 1.16 ± 0.09cm 和 1.26 ± 0.14cm。MW 消融在输出功率为 25W、35W 和 45W 时，平均凝固体积分别为 2.27 ± 0.65cm3、2.85 ± 0.72cm3 和 4.45 ± 0.47cm3，使用 2cm 和 3cm 电极的 RF 消融分别为 1.18 ± 0.30cm3 和 2.29 ± 0.55cm3。MW 消融在 35W 和 45W 时获得的短轴直径明显长于 RF 消融（P < 0.05）。MW 消融在 45W 时达到的组织温度最高（P < 0.05）。组织学检查显示，MW 消融对消融区的影响小于 RF 消融，受组织异质性的影响较小。
与 RF 消融相比，MW 消融在离体牛乳房组织中在消融体积和坏死边缘形状方面具有优势。
