切换交配型转换机制：驯化转座酶取代驯化内切酶。
Switching the mechanism of mating type switching: a domesticated transposase supplants a domesticated homing endonuclease.
机构信息
Institute for Genome Sciences and Policy, and Biochemistry Department, Duke University, Durham, North Carolina 27708, USA.
出版信息
Genes Dev. 2010 Jan 1;24(1):10-4. doi: 10.1101/gad.1886310.
Abstract
Programmed DNA rearrangements are critical for the development of many organisms and, intriguingly, can be catalyzed by domesticated mobile genetic elements. In this issue of Genes & Development, Barsoum and colleagues (pp. 33-44) demonstrate that, in the budding yeast Kluyveromyces lactis, a DNA rearrangement associated with mating type switching requires a domesticated transposase and occurs through a mechanism distinct from that in the related yeast, Saccharomyces cerevisiae. Thus, mechanisms for mating type switching have evolved multiple times, indicating the relative ease with which mobile genetic elements can be captured.
摘要
程序性 DNA 重排对于许多生物的发育至关重要，而且有趣的是，这些重排可以被驯化的移动遗传元件所催化。在本期《基因与发育》中，Barsoum 及其同事（第 33-44 页）表明，在 budding 酵母 Kluyveromyces lactis 中，与交配型转换相关的 DNA 重排需要一种驯化的转座酶，并通过一种与相关酵母 Saccharomyces cerevisiae 不同的机制发生。因此，交配型转换的机制已经多次进化，这表明移动遗传元件很容易被捕获。
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