Quiroga Jairo, Portilla Jaime, Cobo Justo, Glidewell Christopher
Departamento de Química, Universidad de Valle, AA 25360 Cali, Colombia.
Acta Crystallogr C. 2010 Jan;66(Pt 1):o25-8. doi: 10.1107/S0108270109052846. Epub 2009 Dec 12.
(3Z)-3-{1-[(5-Phenyl-1H-pyrazol-3-yl)amino]ethylidene}-4,5-dihydrofuran-2(3H)-one, C(15)H(15)N(3)O(2), (I), and the stoichiometric adduct (3Z)-3-{1-[(5-methyl-1H-pyrazol-3-yl)amino]ethylidene}-4,5-dihydrofuran-2(3H)-one-6-(2-hydroxyethyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7(4H)-one (1/1), C(10)H(13)N(3)O(2).C(10)H(13)N(3)O(2), (II), in which the two components have the same composition but different constitutions, are formed in the reactions of 2-acetyl-4-butyrolactone with 5-amino-3-phenyl-1H-pyrazole and 5-amino-3-methyl-1H-pyrazole, respectively. In each compound, the furanone component contains an intramolecular N-H...O hydrogen bond. The molecules of (I) are linked into a chain by a single intermolecular N-H...O hydrogen bond, while in (II), a combination of one O-H...N hydrogen bond, within the selected asymmetric unit, and two N-H...O hydrogen bonds link the molecular components into a ribbon containing alternating centrosymmetric R(4)(4)(20) and R(6)(6)(22) rings.
（3Z）-3-{1-[(5-苯基-1H-吡唑-3-基)氨基]亚乙基}-4,5-二氢呋喃-2(3H)-酮，C(15)H(15)N(3)O(2)，（I），以及化学计量加合物（3Z）-3-{1-[(5-甲基-1H-吡唑-3-基)氨基]亚乙基}-4,5-二氢呋喃-2(3H)-酮-6-(2-羟乙基)-2,5-二甲基吡唑并[1,5-a]嘧啶-7(4H)-酮（1/1），C(10)H(13)N(3)O(2).C(10)H(13)N(3)O(2)，（II），其中两种组分组成相同但结构不同，它们分别在2-乙酰基-4-丁内酯与5-氨基-3-苯基-1H-吡唑和5-氨基-3-甲基-1H-吡唑的反应中形成。在每种化合物中，呋喃酮组分含有分子内N-H...O氢键。（I）的分子通过单个分子间N-H...O氢键连接成链，而在（II）中，在选定的不对称单元内，一个O-H...N氢键和两个N-H...O氢键的组合将分子组分连接成一条含有交替中心对称R(4)(4)(20)和R(6)(6)(22)环的带状结构。
