[Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers and autonomic nervous system].

Calcium channel blockers are widely used for the treatment of hypertension. Although they are effective for their strong vasodilator action, there are concerns regarding related baroreflex-mediated activation of sympathetic nervous system. However, long-acting calcium channel blockers, such as amlodipine, are now known safe for the treatment of hypertension. Furthermore, the new type of calcium channel blockers, such as cilnidipine with N-type calcium channel blocking action, or azelnidipine that has sympatho-inhibitory action with anti-oxidant effect, provide a new insight for the future use of calcium channel blockers.