Department of Psychiatry, Mysore Medical College & Research Institute, Mysore- 570001, Karnataka, India.
Indian J Psychiatry. 2009 Oct-Dec;51(4):265-71. doi: 10.4103/0019-5545.58291.
With the advent of newer antipsychotic drugs, side effects such as sexual dysfunction have been a major contributor toward treatment compliance. There are only a few studies that have compared different atypical antipsychotic agents regarding sexual dysfunction. We have not come across any data in this area on Indian population.
To determine and compare the frequency of sexual dysfunction associated with risperidone, olanzapine, and quetiapine, among patients with clinically stable schizophrenia.
It is a cross-sectional hospital-based study. The subjects were recruited for the study by the purposive sampling technique.
The total sample size was 102, consisting of 25 each in the quetiapine and risperidone groups, 22 in the olanzapine group, and 30 healthy volunteers. A Brief Psychiatric Rating Scale and Sexual Functioning Questionnaire (SFQ) were administered. The Kruskal Wallis test was used to compare the variables in the demographic data and the mean chlorpromazine equivalent doses of the study groups. To analyze the sexual dysfunction, the mean scores on all the domains of sexual functioning in SFQ were compared across the study groups using the Chi square test, for proportions.
Twenty-three percent of the healthy volunteers had some impairment in one or more domains of sexual functioning. For the medication groups this was 96, 88, and 90%, respectively for risperidone, quetiapine, and olanzapine. However, there was statistically no significant difference across the study groups although it was relatively less with quetiapine.
随着新型抗精神病药物的出现，性功能障碍等副作用已成为影响治疗依从性的主要因素。只有少数研究比较了不同的非典型抗精神病药物在性功能障碍方面的差异。我们在印度人群中没有发现这方面的数据。
确定并比较临床稳定的精神分裂症患者中与利培酮、奥氮平、喹硫平相关的性功能障碍的频率。
这是一项基于医院的横断面研究。采用目的抽样技术招募研究对象。
总样本量为 102 例，其中喹硫平组和利培酮组各 25 例，奥氮平组 22 例，健康对照组 30 例。采用简明精神病评定量表和性功能问卷（SFQ）进行评估。采用 Kruskal Wallis 检验比较人口统计学数据和研究组平均氯丙嗪等效剂量的变量。为了分析性功能障碍，采用卡方检验比较 SFQ 中所有性功能领域的平均得分，以比较研究组之间的差异。
23%的健康志愿者在一个或多个性功能领域存在一定程度的障碍。对于药物组，利培酮、喹硫平、奥氮平组分别为 96%、88%和 90%。然而，尽管喹硫平组的差异相对较小，但研究组之间的差异没有统计学意义。
