Discipline of Exercise and Sport Science, University of Sydney, Lidcombe, New South Wales, Australia.
Spinal Cord. 2010 Aug;48(8):591-6. doi: 10.1038/sc.2009.180. Epub 2010 Jan 5.
Cross-sectional, observational study.
To evaluate the associations of physical activity and neurological lesion level with glucose tolerance in people with spinal cord injury (SCI).
New South Wales, Australia.
Twenty-five people (5 women, 20 men) with SCI (>6 months post-injury) aged between 18 and 65 years were recruited. Exclusion criteria included known coronary heart disease, stroke or diabetes. Participants underwent an oral glucose tolerance test. Fasting and 2-h plasma glucose concentrations were classified according to the World Health Organization categories of glycemia. Participants also completed the Physical Activity Scale for Individuals with Physical Disabilities and mean MET-hours day(-1) was calculated. Associations with the 2-h plasma glucose concentration were calculated through multiple and stepwise regressions.
Participants presented with complete or incomplete tetraplegia (n=11 TETRA) or complete or incomplete paraplegia (n=14 PARA) with neurological lesion levels ranging from C3/4 to T12. Mean 2-h plasma glucose was 7.13+/-2.32 mmol l(-1). Nine participants had disordered glycemia (n=6 TETRA; n=3 PARA) and the remaining participants had normal glucose tolerance. Those participants with normal glucose tolerance participated in more moderate-vigorous and strength exercise and undertook more non-exercise-related mobility than those with disordered glycemia. Physical activity and age, but not lesion level were independent determinants of 2-h plasma glucose concentration (r=0.683, P=0.001), explaining 47% of the variance.
Physical activity level is independently associated with glucose tolerance in people with SCI. Non-exercise activity may also be important for maintaining normal glycemia.
横断面观察性研究。
评估体力活动和神经损伤水平与脊髓损伤（SCI）患者葡萄糖耐量的相关性。
澳大利亚新南威尔士州。
招募了 25 名（5 名女性，20 名男性）年龄在 18 至 65 岁之间、SCI 时间超过 6 个月的患者。排除标准包括已知的冠心病、中风或糖尿病。参与者接受了口服葡萄糖耐量试验。空腹和 2 小时血浆葡萄糖浓度根据世界卫生组织的血糖分类进行分类。参与者还完成了个体身体残疾活动量表，计算了平均代谢当量小时/天（MET-hours day(-1)）。通过多元和逐步回归计算与 2 小时血浆葡萄糖浓度的相关性。
参与者表现为完全或不完全四肢瘫痪（n=11 例 TETRA）或完全或不完全截瘫（n=14 例 PARA），神经损伤水平从 C3/4 到 T12。平均 2 小时血浆葡萄糖为 7.13+/-2.32mmol l(-1)。9 名参与者血糖异常（n=6 例 TETRA；n=3 例 PARA），其余参与者葡萄糖耐量正常。血糖正常的参与者参与了更多的中等强度到剧烈运动和力量训练，并且进行了更多与运动无关的活动，而非血糖异常的参与者。体力活动和年龄，而不是损伤水平，是 2 小时血浆葡萄糖浓度的独立决定因素（r=0.683，P=0.001），解释了 47%的方差。
体力活动水平与 SCI 患者的葡萄糖耐量独立相关。非运动活动可能对维持正常血糖也很重要。
