Lee Jong Ho, Cho Jang Hyuk, Lee Dong Gyu
Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea.
Department of Rehabilitation Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Medical Center, Daegu 42601, Korea.
Healthcare (Basel). 2022 May 25;10(6):983. doi: 10.3390/healthcare10060983.
Patients with spinal cord injury (SCI) experience a high osteoporosis incidence, which increases fracture risk. Recently, a sclerostin antibody was introduced as a target biomarker to treat osteoporosis. We aimed to determine the serum concentration of sclerostin and factors affecting its concentration over time. This was a prospective cross-sectional study. The inclusion criteria were (1) SCI patients with a grade 3 modified functional ambulatory category score (FAC—patients requiring firm continuous support) and (2) patients whose injury occurred >1 month ago. The exclusion criterion was a history of osteoporosis medication administration within 6 months. The collected data included bone biomarkers (carboxy-terminal collagen crosslinks (CTX), procollagen type 1 intact N-terminal propeptide, and sclerostin), clinical data (FAC, lower extremity motor score), body mass index, SCI duration, and hip bone mineral density (BMD). This study recruited 62 patients with SCI. Sclerostin levels significantly correlated with age, CTX level, and hip BMD. SCI duration was negatively correlated with sclerostin levels. Lower extremity motor scores were not significantly correlated with sclerostin levels. The acute SCI state showed a higher sclerostin level than the chronic SCI state. Sclerostin showed a significant relationship with CTX. In conclusion, age and BMD affect sclerostin concentration in patients with SCI.
脊髓损伤（SCI）患者骨质疏松症发病率很高，这增加了骨折风险。最近，一种硬化素抗体被作为治疗骨质疏松症的靶向生物标志物引入。我们旨在确定硬化素的血清浓度以及随时间影响其浓度的因素。这是一项前瞻性横断面研究。纳入标准为：（1）改良功能步行分类评分（FAC）为3级的SCI患者（需要持续有力支撑的患者）；（2）损伤发生超过1个月的患者。排除标准为6个月内有骨质疏松症药物治疗史。收集的数据包括骨生物标志物（羧基末端胶原交联（CTX）、1型前胶原完整N端前肽和硬化素）、临床数据（FAC、下肢运动评分）、体重指数、SCI持续时间和髋部骨密度（BMD）。本研究招募了62例SCI患者。硬化素水平与年龄、CTX水平和髋部BMD显著相关。SCI持续时间与硬化素水平呈负相关。下肢运动评分与硬化素水平无显著相关性。急性SCI状态的硬化素水平高于慢性SCI状态。硬化素与CTX存在显著关系。总之，年龄和BMD影响SCI患者的硬化素浓度。
