Department of Dermatology, Silesian Medical University in Katowice, Francuska Street 20/24, 40-027 Katowice, Poland.
Rheumatol Int. 2012 Feb;32(2):473-7. doi: 10.1007/s00296-009-1335-3. Epub 2010 Jan 5.
Sonozaki syndrome--pustulotic arthro-osteitis (PAO) is a relatively rare, chronic illness. This disease belongs to the group of psoriatic arthritis (psoriasis arthropatica, artropatia psoriatica) which in turn belongs to the group of seronegative arthritis. Sonozaki syndrome includes palmoplantar pustulosis, PPP as well as arthro-osteitis. Clinically, symmetrically localised pustulae are observed on feet and hands. Effected joints are painful, swollen with a visible inflammation. Here, we describe a case of a woman aged 55 with a diagnosis of Sonozaki syndrome and hyperthyroidism. At the moment of admission multiple changes in the form of pustulae were observed on hands and soles, filled with pus and blood of the erythemal basis. Oral and genital mucosa were free from changes. The oedema within clavicle and sternum joints was without features of the severe inflammation and tactical tenderness. In additional tests, increased BSR 36/62 was found. Bone scintigraphy-focuses of increased accumulation of MDP-Tc-99 m were found in the sternal projection of the clavicle ends at both sides, and the left-side change is bigger and more strongly saturated and can probably progress to the sternum's manubrium. As a result of the used treatment during hospitalisation, (cyclosporine 3 mg/kg and steroid external therapy upon the skin changes) the improvement of the local changes was observed as well as no progression in the joints' changes. At the moment, the patient is treated in the dermatological and rheumatological out-clinic. Early and correct diagnostics allows for efficient treatment of Sonozaki syndrome and decreases the risk of potential complications, such as the described systemic amyloidosis.
曾岛崎综合征——脓疱性关节炎（PAO）是一种相对罕见的慢性疾病。该疾病属于银屑病关节炎（银屑病性关节炎，artropatia psoriatica）范畴，而银屑病关节炎又属于血清阴性关节炎范畴。曾岛崎综合征包括掌跖脓疱病（PPP）和关节炎。临床上，在手和脚上观察到对称的局部脓疱。受影响的关节疼痛、肿胀，伴有明显炎症。在这里，我们描述了一名 55 岁女性患有曾岛崎综合征和甲状腺功能亢进症的病例。入院时，手部和脚底观察到多个脓疱变化，脓疱充满了红斑基底的脓液和血液。口腔和生殖器黏膜无变化。锁骨和胸骨关节的水肿无严重炎症和局部压痛的特征。在其他检查中，发现 BSR 升高至 36/62。骨闪烁扫描——在双侧锁骨末端胸骨投影处发现 MDP-Tc-99m 聚集增加的焦点，左侧变化更大且更强烈饱和，可能进展至胸骨柄。由于住院期间使用的治疗方法（环孢素 3mg/kg 和皮肤变化的皮质类固醇外用治疗），观察到局部变化的改善，关节变化没有进展。目前，该患者在皮肤科和风湿科门诊接受治疗。早期和正确的诊断可以实现对曾岛崎综合征的有效治疗，并降低潜在并发症的风险，如所述的系统性淀粉样变性。
