Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany.
Horm Metab Res. 2010 Jun;42(6):429-34. doi: 10.1055/s-0029-1243257. Epub 2010 Jan 4.
Patients presenting with primary aldosteronism experience more cardiovascular events than patients with essential hypertension independent of blood pressure. Therefore, the presence of primary aldosteronism should be detected, not only to determine the cause of hypertension, but also to prevent such complications. This review focuses on human data regarding increased end-organ damage and comorbidities in primary aldosteronism. Special emphasis is put on the effects of aldosterone excess on blood vessels, the heart, the kidney, and the brain. The data reviewed in our article demonstrate that primary aldosteronism is associated with a prevalence of cerebro-, cardiovascular and renal complications that are out of proportion to the blood pressure and benefits substantially from treatment in the long term. In this view, adrenalectomy and aldosterone antagonist treatment seem to be of considerable therapeutic value to control and limit the progression of comorbidities in primary aldosteronism.
原发性醛固酮增多症患者发生心血管事件的几率高于原发性高血压患者，且与血压无关。因此，不仅要确定高血压的病因，还要预防此类并发症，应检测出原发性醛固酮增多症的存在。本综述重点介绍了原发性醛固酮增多症患者的终末器官损伤和合并症增加的人体数据。特别强调了醛固酮过多对血管、心脏、肾脏和大脑的影响。我们文章中综述的数据表明，原发性醛固酮增多症与脑血管、心血管和肾脏并发症的发生率不成比例，这些并发症的患病率高于血压，且长期治疗获益显著。从这个角度来看，肾上腺切除术和醛固酮拮抗剂治疗似乎具有相当大的治疗价值，可控制和限制原发性醛固酮增多症的合并症进展。
