Dugan S J, Curtis C R, Roberts S M, Severin G A
Department of Clinical Sciences, Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
J Am Vet Med Assoc. 1991 Jan 15;198(2):251-6.
Proportional hospital accession ratios for equine ocular/adnexal squamous cell carcinoma (SCC) were determined for 14 colleges of veterinary medicine participating in the Veterinary Medical Data Program between January 1978 and December 1986. Comparison of the ratios with their respective geographical, physical data has shown an increased prevalence of SCC with an increase in longitude, altitude, or mean annual solar radiation. In contrast, prevalence of SCC increased with a decrease in latitude. Between January 1978 and December 1988, 147 horses with ocular/adnexal SCC were admitted to the Colorado State University Veterinary Teaching Hospital. Diagnosis was confirmed by histologic examination of appropriate tissue specimens. Medical records provided information regarding month and year of admission and diagnosis, age at diagnosis, breed, gender, and hair color. Comparison with a randomly selected hospital control population revealed an increased prevalence of ocular/adnexal SCC with an increase in age (P less than 0.001). Compared with Quarter Horses, draft breeds (Belgian, Clydesdale, and Shire) and Appaloosas had a significantly (P less than 0.001) greater prevalence of ocular/adnexal SCC. Sexually intact males and females were significantly (P less than 0.001) less likely (5 and 2 times, respectively) to have ocular/adnexal SCC when compared with castrated males. The prevalence of ocular/adnexal SCC was significantly greater for all hair colors when compared with bay, brown, or black (P less than 0.01).
对1978年1月至1986年12月期间参与兽医医学数据项目的14所兽医学院收治的马眼部/附属器鳞状细胞癌（SCC）的比例进行了测定。将这些比例与其各自的地理、物理数据进行比较后发现，SCC的患病率随着经度、海拔或年平均太阳辐射的增加而上升。相比之下，SCC的患病率随着纬度的降低而增加。1978年1月至1988年12月期间，147匹患有眼部/附属器SCC的马被收治到科罗拉多州立大学兽医教学医院。通过对适当组织标本进行组织学检查确诊。病历提供了入院和诊断的月份及年份、诊断时的年龄、品种、性别和毛色等信息。与随机选择的医院对照群体进行比较发现，眼部/附属器SCC的患病率随着年龄的增加而上升（P小于0.001）。与夸特马相比，挽马品种（比利时马、克莱兹代尔马和夏尔马）和阿帕卢萨马的眼部/附属器SCC患病率显著更高（P小于0.001）。与去势雄性马相比，未阉割的雄性和雌性马患眼部/附属器SCC的可能性显著更低（分别为5倍和2倍）（P小于0.001）。与枣色、棕色或黑色相比，所有毛色的马眼部/附属器SCC患病率均显著更高（P小于0.01）。
