Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
J Mol Cell Biol. 2010 Oct;2(5):231-3. doi: 10.1093/jmcb/mjp054. Epub 2010 Jan 5.
Activation of Janus kinase 2 (JAK2) plays a critical role in normal hematopoiesis and leukemogenesis. Dawson et al. (2009; JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-822) report that JAK2 performs this function by displacing the heterochromatin protein HP1α from chromatin through phosphorylation of histone H3.
Janus 激酶 2（JAK2）的激活在正常造血和白血病发生中起着关键作用。Dawson 等人（2009 年；JAK2 磷酸化组蛋白 H3Y41，将 HP1α 从染色质中排除。自然 461，819-822）报道说，JAK2 通过磷酸化组蛋白 H3 将异染色质蛋白 HP1α 从染色质中置换出来，从而发挥此功能。
