Janus 激酶 2：一种激活白血病相关基因的表观遗传“书写者”。
Janus kinase 2: an epigenetic 'writer' that activates leukemogenic genes.
机构信息
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
出版信息
J Mol Cell Biol. 2010 Oct;2(5):231-3. doi: 10.1093/jmcb/mjp054. Epub 2010 Jan 5.
Activation of Janus kinase 2 (JAK2) plays a critical role in normal hematopoiesis and leukemogenesis. Dawson et al. (2009; JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-822) report that JAK2 performs this function by displacing the heterochromatin protein HP1α from chromatin through phosphorylation of histone H3.
Janus 激酶 2（JAK2）的激活在正常造血和白血病发生中起着关键作用。Dawson 等人（2009 年；JAK2 磷酸化组蛋白 H3Y41，将 HP1α 从染色质中排除。自然 461，819-822）报道说，JAK2 通过磷酸化组蛋白 H3 将异染色质蛋白 HP1α 从染色质中置换出来，从而发挥此功能。
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