Wei G, Kotoura Y, Oka M, Yamamuro T, Wada R, Hyon S H, Ikada Y
Research Centre for Medical Polymers and Biomaterials, Kyoto University, Japan.
J Bone Joint Surg Br. 1991 Mar;73(2):246-52. doi: 10.1302/0301-620X.73B2.2005148.
We prepared a composite of D,L-lactic acid oligomer and dideoxykanamycin B for use as a biodegradable antibiotic delivery system with sustained effect. The composite was implanted in the distal portion of the rabbit femur, and the effective concentration of the antibiotic was measured in the cortex, the cancellous bone, and the bone marrow. In all bone tissues around the implant, the concentration of antibiotic exceeded the minimum inhibitory concentration for the common causative organisms of osteomyelitis for six weeks. Most of the implant material had been absorbed and the bone marrow had been repaired to a nearly normal state within nine weeks of implantation. The implant caused no systemic side effects, and it is likely to prove clinically useful as a drug delivery system for treating chronic osteomyelitis.
我们制备了一种由D，L-乳酸低聚物和双脱氧卡那霉素B组成的复合物，用作具有持续效果的可生物降解抗生素递送系统。将该复合物植入兔股骨远端，然后测量皮质骨、松质骨和骨髓中抗生素的有效浓度。在植入物周围的所有骨组织中，抗生素浓度在六周内超过了骨髓炎常见致病菌的最低抑菌浓度。植入九周内，大部分植入材料已被吸收，骨髓已修复至接近正常状态。该植入物未引起全身副作用，作为治疗慢性骨髓炎的药物递送系统，很可能在临床上证明是有用的。
