Dermatology and Venereology Unit, Department of Medicine, Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. beni.amatya @ ki.se
Skin Pharmacol Physiol. 2010;23(3):133-8. doi: 10.1159/000270385. Epub 2009 Dec 23.
Various mediators have been suggested for the pathogenesis of pruritus in psoriasis.
To investigate cutaneous responses of substance P in pruritic lesional and nonlesional areas of psoriasis patients and in healthy controls, substance P, saline and histamine were injected intradermally. After each injection, pruritus, flare and wheal were recorded.
There was no statistical difference in the latency period, duration, area under the curve and maximum intensity of pruritus evoked by substance P (10(-5) and 10(-6) mol/l) between psoriasis and healthy control skin. Substance P (10(-5) mol/l) induced a tendency to a greater intensity of pruritus in lesional compared to nonlesional psoriatic skin (p = 0.08). Histamine produced a shorter itch latency period (p < 0.05) and a lower maximum intensity of pruritus (p = 0.05) in lesional psoriasis skin than in healthy control skin. No significant difference in flare area was observed between the psoriasis patients and healthy controls. The histamine-induced wheal was smaller in psoriasis patients than in healthy individuals (p < 0.05).
Intradermally injected substance P induced pruritus, flare and wheal in psoriasis patients. However, these responses did not differ significantly from those of the healthy controls.
多种介质被认为与银屑病瘙痒的发病机制有关。
为了研究物质 P 在银屑病瘙痒性皮损和非皮损区的皮肤反应以及在健康对照组中的皮肤反应，我们对物质 P、生理盐水和组胺进行了皮内注射。每次注射后，记录瘙痒、红斑和风团。
在银屑病和健康对照组的皮肤中，物质 P（10(-5) 和 10(-6) mol/l）引起的瘙痒潜伏期、持续时间、曲线下面积和最大强度均无统计学差异。物质 P（10(-5) mol/l）在皮损区引起的瘙痒强度较非皮损区银屑病皮肤有增加的趋势（p = 0.08）。与健康对照组皮肤相比，组胺在皮损性银屑病皮肤中引起的瘙痒潜伏期更短（p < 0.05）和最大瘙痒强度更低（p = 0.05）。在银屑病患者和健康对照组之间，红斑面积无显著差异。与健康个体相比，在银屑病患者中，组胺引起的风团较小（p < 0.05）。
皮内注射物质 P 可引起银屑病患者瘙痒、红斑和风团。然而，这些反应与健康对照组相比没有显著差异。
