Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, Scotland, UK.
Behav Genet. 2010 Jul;40(4):518-32. doi: 10.1007/s10519-009-9326-4. Epub 2010 Jan 6.
Genetic variants that have previously been associated with personality traits and/or psychological distress, or inflammatory marker levels were investigated for their relationship to self-rated personality traits, anxiety, and depression in two elderly Scottish cohorts. Ten genes (29 SNPs) were investigated in the Lothian Birth Cohort 1936 (approximately 70 years, N = 1,091). Four of these genes and seven others (35 SNPs) were tested in the Lothian Birth Cohort 1921 who were measured on the same traits and states on two occasions (approximately 80 years, N = 550; 87 years, N = 229). For previously investigated candidate genes, some support (at a nominal significance level of 0.05/0.01) was found for association between NOS1 and personality traits (especially extraversion), PSEN1 and depression/neuroticism, and GRIK3 and depression. Of the inflammatory marker candidate genes, TF showed some association with psychological distress. No SNPs withstood the correction to significance level for multiple testing. Nevertheless, the results will be of importance to future meta-analyses of these candidate genes in relation to psychological distress and personality.
先前与人格特质和/或心理困扰或炎症标志物水平相关的遗传变异，在两个苏格兰老年队列中被研究其与自评人格特质、焦虑和抑郁的关系。在洛锡安出生队列 1936 中研究了 10 个基因（29 个 SNP）（约 70 岁，N = 1091）。其中 4 个基因和另外 7 个基因（35 个 SNP）在洛锡安出生队列 1921 中进行了测试，该队列在两次测量中（约 80 岁，N = 550；87 岁，N = 229）测量了相同的特质和状态。对于先前研究的候选基因，NOS1 与人格特质（尤其是外向性）、PSEN1 与抑郁/神经质和 GRIK3 与抑郁之间存在一些关联（在名义显著性水平 0.05/0.01 下）。在炎症标志物候选基因中，TF 与心理困扰有一定关联。没有 SNP 经受住了多重检验校正的显著性水平。然而，这些结果对于这些候选基因与心理困扰和人格相关的未来荟萃分析将具有重要意义。
