Li Xinxin, Sun Ning, Yang Chunxia, Liu Zhifen, Li Xinrong, Zhang Kerang
Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China.
Shanxi Medical University, Taiyuan, China.
Psychiatry Investig. 2019 Dec;16(12):940-947. doi: 10.30773/pi.2019.0117. Epub 2019 Nov 13.
Although the pathogenesis of depression remains unclear, C-reactive protein (CRP) levels are commonly elevated in depressed patients. Thus, CRP single-nucleotide polymorphisms (SNPs) that influence CRP levels may be associated with depression. In the present study, we explored whether CRP SNPs are related to depressive symptoms and antidepressants efficacy in Han Chinese patients.
We analyzed data from 440 patients with first-episode depression. We obtained genome CRP SNPs, scores of the 17-item Hamilton Rating Scale for Depression 17 (HAMD17) and its four-factor at baseline and after 6 weeks. Quantitative trait analysis was performed using UNPHASED software and curative effects were analyzed using SPSS software.
Male patients with SNP rs1800947G exhibited lower insomnia scores and rs2794521CC exhibited lower scores of anxiety/ physical symptoms, total HAMD17 score. Female patients with rs2794521TT exhibited higher scores of insomnia and lower antidepressants efficacy.
CRP SNPs rs1800947 and rs2794521 may be associated with depressive symptoms in patients with depression in a sexspecific fashion. Furthermore, rs2794521 may be a predictor of the efficacy of antidepressants in female patients.
尽管抑郁症的发病机制尚不清楚，但抑郁症患者的C反应蛋白（CRP）水平通常会升高。因此，影响CRP水平的CRP单核苷酸多态性（SNP）可能与抑郁症有关。在本研究中，我们探讨了CRP SNP是否与中国汉族患者的抑郁症状及抗抑郁药疗效相关。
我们分析了440例首发抑郁症患者的数据。我们获取了基因组CRP SNP、基线及6周后17项汉密尔顿抑郁量表（HAMD17）评分及其四因子评分。使用UNPHASED软件进行数量性状分析，使用SPSS软件分析疗效。
携带SNP rs1800947G的男性患者失眠评分较低，携带rs2794521CC的男性患者焦虑/躯体症状评分及HAMD17总分较低。携带rs2794521TT的女性患者失眠评分较高且抗抑郁药疗效较低。
CRP SNP rs1800947和rs2794521可能以性别特异性方式与抑郁症患者的抑郁症状相关。此外，rs2794521可能是女性患者抗抑郁药疗效的一个预测指标。
