Shanghai Key Laboratory of Green Chemistry and Chemical, Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai, 200062, China.
Chem Asian J. 2010 Mar 1;5(3):422-34. doi: 10.1002/asia.200900458.
Multicatalyst promoted asymmetric tandem reactions have emerged as a powerful strategy to improve the synthetic efficiency. It enables the synthesis of complex molecules with high selectivity from simple starting materials in an almost biomimetic-like way. The use of multiple catalyst systems can enlarge the substrate and reaction scope for the reaction design, improve the reactivity, and benefit the control of selectivity. In this Focus Review, the current achievement of this promising field is discussed, including the advantages and difficulties of this research, and the strategies applied to address these problems.
多催化剂促进的不对称串联反应已成为提高合成效率的一种强大策略。它可以从简单的起始原料中以几乎类似生物模拟的方式高效高选择性地合成复杂分子。使用多个催化剂体系可以扩大反应设计的底物和反应范围，提高反应活性，并有利于控制选择性。在这篇重点综述中，讨论了这一有前途的领域的最新成果，包括该研究的优势和难点，以及应用于解决这些问题的策略。
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