Dept. of Medical Microbiology, Leiden University Medical Center, Leiden, Albinusdreef Leiden, The Netherlands.
J Clin Virol. 2010 Mar;47(3):216-8. doi: 10.1016/j.jcv.2009.12.004. Epub 2010 Jan 6.
Betapapillomaviruses may be associated with the development of cutaneous squamous cell carcinoma but little is known about their transmission. One suggestion is that they are transmitted through close skin contact.
To test this hypothesis we assessed whether co-habiting opposite-sex couples were more or less likely to share betaPV types than each member of the couple and an age-matched, opposite-sex control.
Betapapillomavirus was measured in eyebrow hairs of 57 couples and 114 age- and sex-matched controls. We compared the proportion of partners who shared at least one betaPV type with the proportion of control partnerships sharing a betaPV type. We further subdivided those who shared at least one type into those who shared only one and those who shared more than one. We tested the significance of differences in these proportions using Chi-squared tests. A case-wise concordance index was used to calculate the overall concordance of the partners and the control pairings.
At least one betaPV type was shared by 39% of the co-habiting couples and 26% of the control pairs (p=0.10). When restricted to all people with at least one virus infection (26 couples) 74% of the partners and 46% of the control pairs shared at least one type (p=0.02). The case-wise concordance index for partners was 0.28 (95% CI 0.21-0.35) and for the matched control pairs 0.16 (95% CI 0.12-0.20) (p<0.001).
Our results support the hypothesis that skin-to-skin contact is the primary means of betapapillomavirus transmission.
β 型乳头瘤病毒可能与皮肤鳞状细胞癌的发展有关，但人们对其传播途径知之甚少。一种说法是，它们通过密切的皮肤接触传播。
为了验证这一假设，我们评估了同居的异性伴侣是否比夫妻双方各自更有可能与年龄匹配的异性对照组共享β型乳头瘤病毒类型。
在 57 对夫妇和 114 名年龄和性别匹配的对照组的眉毛头发中测量了β 型乳头瘤病毒。我们比较了伴侣中至少有一个βPV 型共享的比例与对照组中共享βPV 型的比例。我们进一步将那些至少共享一种类型的人分为仅共享一种类型和共享多种类型的人。我们使用卡方检验测试这些比例差异的显著性。使用病例一致指数计算伴侣和对照组配对的整体一致性。
至少有一种βPV 型在同居夫妇中占 39%，在对照组中占 26%（p=0.10）。当仅限于所有至少有一种病毒感染的人（26 对夫妇）时，74%的伴侣和 46%的对照组至少共享一种类型（p=0.02）。伴侣的病例一致指数为 0.28（95%CI 0.21-0.35），而匹配的对照组为 0.16（95%CI 0.12-0.20）（p<0.001）。
我们的结果支持皮肤与皮肤接触是β 型乳头瘤病毒传播的主要途径的假设。
