Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.
Int J Occup Med Environ Health. 2009;22(4):383-91. doi: 10.2478/v10001-009-0037-0.
Exposures during prenatal period have implications for pregnancy outcome as well as for children's health, morbidity and mortality. Prospective cohort study design allows for the identification of exposures that may influence pregnancy outcome and children's health, verification of such exposures by biomarker measurements and notification of any changes in exposure level.
Polish Mother and Child Cohort Study (REPRO_PL) is multicenter prospective cohort study conducted in 8 different regions of Poland. The final cohort is intended to comprise 1300 mother-child pairs to be recruited within 4-year period (2007-2011). The recruitment and all scheduled visits are conducted in maternity units or clinics in the districts included in the study. The women are followed-up 3 times in pregnancy (once in each trimester) and after delivery for the notification of pregnancy outcome. During each visit, detailed questionnaire and biological samples are collected including saliva, urine, hair, maternal blood and cord blood. About 6 weeks postpartum, breast milk from part of the women is collected. The study concentrates on the identification and evaluation of the effects of prenatal environmental exposure on pregnancy outcome and children's health. Specific research hypotheses refer to the role of heavy metals, exposure to polycyclic aromatic hydrocarbons (PAHs) and environmental tobacco smoke (ETS) in the aetiology of small-for-gestational-age (SGA) and preterm delivery (PD). The role of oxidative stress putative mechanism and pregnant women nutritional status will be investigated. Based on questionnaire data, the impact of occupational exposures and stressful situations will be evaluated.
The results of the study will become available within the next few years and will help to determine levels of child prenatal exposure in several areas of Poland and its impact on course and outcome of pregnancy.
孕期暴露不仅对妊娠结局，而且对儿童的健康、发病率和死亡率都有影响。前瞻性队列研究设计可识别可能影响妊娠结局和儿童健康的暴露因素，通过生物标志物测量来验证这些暴露因素，并通知任何暴露水平的变化。
波兰母婴队列研究（REPRO_PL）是一项多中心前瞻性队列研究，在波兰 8 个不同地区进行。最终的队列计划包括在 4 年内招募 1300 对母婴。招募和所有预定的访视都在包括在研究中的地区的妇产科医院或诊所进行。在妊娠期间，这些女性将接受 3 次随访（每次妊娠阶段一次），并在分娩后通知妊娠结局。每次就诊时，都会收集详细的问卷和生物样本，包括唾液、尿液、头发、母亲血液和脐带血。大约在产后 6 周，从部分女性中收集母乳。该研究集中于识别和评估产前环境暴露对妊娠结局和儿童健康的影响。具体的研究假设涉及重金属、多环芳烃（PAHs）和环境烟草烟雾（ETS）暴露在胎儿生长受限（SGA）和早产（PD）发病机制中的作用。氧化应激的作用和孕妇的营养状况将被调查。基于问卷数据，将评估职业暴露和紧张局势的影响。
该研究的结果将在未来几年内公布，有助于确定波兰几个地区儿童产前暴露的水平及其对妊娠过程和结局的影响。
