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秀丽隐杆线虫肠道的命运决定和组织特异性细胞周期调控。

Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine.

机构信息

Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

出版信息

Mol Biol Cell. 2010 Mar 1;21(5):725-38. doi: 10.1091/mbc.e09-04-0268. Epub 2010 Jan 6.

DOI:10.1091/mbc.e09-04-0268
PMID:20053685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2828960/
Abstract

Coordination between cell fate specification and cell cycle control in multicellular organisms is essential to regulate cell numbers in tissues and organs during development, and its failure may lead to oncogenesis. In mammalian cells, as part of a general cell cycle checkpoint mechanism, the F-box protein beta-transducin repeat-containing protein (beta-TrCP) and the Skp1/Cul1/F-box complex control the periodic cell cycle fluctuations in abundance of the CDC25A and B phosphatases. Here, we find that the Caenorhabditis elegans beta-TrCP orthologue LIN-23 regulates a progressive decline of CDC-25.1 abundance over several embryonic cell cycles and specifies cell number of one tissue, the embryonic intestine. The negative regulation of CDC-25.1 abundance by LIN-23 may be developmentally controlled because CDC-25.1 accumulates over time within the developing germline, where LIN-23 is also present. Concurrent with the destabilization of CDC-25.1, LIN-23 displays a spatially dynamic behavior in the embryo, periodically entering a nuclear compartment where CDC-25.1 is abundant.

摘要

在多细胞生物中，细胞命运特化和细胞周期调控之间的协调对于调节发育过程中组织和器官中的细胞数量至关重要，其失败可能导致肿瘤发生。在哺乳动物细胞中，作为一般细胞周期检查点机制的一部分，F -box 蛋白 β-联素重复蛋白（β-TrCP）和 Skp1/Cul1/F-box 复合物控制着 CDC25A 和 B 磷酸酶丰度的周期性细胞周期波动。在这里，我们发现秀丽隐杆线虫β-TrCP 同源物 LIN-23 调节 CDC-25.1 丰度的逐渐下降，跨越几个胚胎细胞周期，并指定一个组织（胚胎肠道）的细胞数量。LIN-23 对 CDC-25.1 丰度的负调控可能受到发育控制，因为 CDC-25.1 在发育中的生殖系中随时间积累，而 LIN-23 也存在于其中。与 CDC-25.1 的不稳定性同时发生，LIN-23 在胚胎中表现出空间动态行为，周期性地进入富含 CDC-25.1 的核区室。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/1ad6ad5d8af5/zmk0051093630007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/611d4d1c9401/zmk0051093630001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/32b88cfb0b73/zmk0051093630002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/5961eb28aede/zmk0051093630003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/5ab6b4f6a9c5/zmk0051093630004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/8d20ff9a38ff/zmk0051093630005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/c304de596fbb/zmk0051093630006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/1ad6ad5d8af5/zmk0051093630007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/611d4d1c9401/zmk0051093630001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/32b88cfb0b73/zmk0051093630002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/5961eb28aede/zmk0051093630003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/5ab6b4f6a9c5/zmk0051093630004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/8d20ff9a38ff/zmk0051093630005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/c304de596fbb/zmk0051093630006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef5/2828960/1ad6ad5d8af5/zmk0051093630007.jpg

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