产前雌激素增加与精神分裂症风险因素的关联。
Association of increased prenatal estrogen with risk factors for schizophrenia.
机构信息
Clinical Services, Crossroads Community Services Board, Farmville, VA, USA.
出版信息
Schizophr Bull. 2011 Sep;37(5):946-9. doi: 10.1093/schbul/sbp161. Epub 2010 Jan 6.
Abstract
The author previously described a theoretical cause of schizophrenia based on the effects of estrogenic endocrine disruption. In the current review, the author describes how increased estrogen during pregnancy increases susceptibility to certain viral infections associated with increased risk for schizophrenia. The review further discusses how prenatal estrogen exposure could explain associations of schizophrenia with autoimmune diseases, urban environments, and stress. Based on the association of increased estrogen with schizophrenia risk factors, the author proposes increased prenatal estrogen as a unifying factor, perhaps the primary event, in the etiology of schizophrenia.
摘要
作者之前基于雌激素内分泌干扰的影响，描述了精神分裂症的一个理论成因。在当前的综述中，作者描述了怀孕期间雌激素水平升高如何增加了对某些与精神分裂症风险增加相关的病毒感染的易感性。该综述进一步讨论了产前雌激素暴露如何解释精神分裂症与自身免疫性疾病、城市环境和压力之间的关联。基于雌激素增加与精神分裂症风险因素的关联，作者提出产前雌激素增加是精神分裂症病因学中的一个统一因素，也许是主要事件。
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3
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