Chemistry Department, Islamic Azad University, Tonekabon Branch, Mazandaran, Iran.
Int J Nanomedicine. 2009;4:283-7. doi: 10.2147/ijn.s5895. Epub 2009 Dec 29.
The decrease in particle size may offer new properties to drugs. In this study, we investigated the size reduction influence of the acetaminophen (C(8)H(9)O(2)N) particles by mechanical activation using a dry ball mill. The activated samples with the average size of 1 microm were then investigated in different time periods with the infrared (IR), inductively coupled plasma (ICP), atomic force microscopy (AFM), and X-ray diffraction (XRD) methods. The results of the IR and XRD images showed no change in the drug structure after the mechanical activation of all samples. With the peak height at full width at half maximum from XRD and the Scherrer equation, the size of the activated crystallite samples illustrated that the AFM images were in sound agreement with the Scherrer equation. According to the peaks of the AFM images, the average size of the particles in 30 hours of activation was 24 nm with a normal particle distribution. The ICP analysis demonstrated the presence of tungsten carbide particle impurities after activation from the powder sample impacting with the ball and jar. The greatest reduction in size was after milling for 30 hours.
粒径的减小可能会为药物带来新的性质。在这项研究中，我们通过使用干法球磨机对醋氨酚（C（8）H（9）O（2）N）颗粒进行机械激活，研究了颗粒尺寸减小的影响。然后，将平均粒径为 1 微米的激活样品在不同时间段内使用红外（IR）、电感耦合等离子体（ICP）、原子力显微镜（AFM）和 X 射线衍射（XRD）方法进行研究。IR 和 XRD 图像的结果表明，所有样品的机械激活后药物结构没有变化。根据 XRD 的峰高半最大值和谢勒方程，激活的微晶样品的尺寸表明 AFM 图像与谢勒方程非常吻合。根据 AFM 图像的峰，在 30 小时的激活过程中，颗粒的平均尺寸为 24nm，具有正常的颗粒分布。ICP 分析表明，从粉末样品与球和罐的碰撞中，存在碳化钨颗粒杂质。在 30 小时的研磨后，粒径的减小达到最大。
