Department of Research and Development, VEB JENAPHARM, Otto-Schott-Straβe 13, DDR-6900, Jena.
Pharm Res. 1985 Nov;2(6):302-6. doi: 10.1023/A:1016397719020.
Mechanical activation has become a phenomenon of general significance in pharmaceutics. This report describes the extent of activation induced by relevant processes. With the use of the Eyring equation the transformation of structurally stored energy into chemical energy and the implied free enthalpy as well as the excess free enthalpy (activity) were evaluated from the rate of an indicator reaction. A comparison was made between different kinds of milling and tabletting with respect to pharmaceutical conditions. An optimization of these processes was derived.
机械激活已成为药剂学中具有普遍意义的现象。本报告描述了相关过程所引起的激活程度。通过 Eyring 方程，从指示剂反应的速率来评估结构存储能向化学能的转化以及隐含的自由焓和过剩自由焓（活性）。比较了不同的粉碎和压片方式在药物条件下的差异。并对这些过程进行了优化。
