Figueiredo Sandra, Fernandes Gabriela, Morais António
Pulmonology, Serviço de Pneumologia do Hospital de São João, Porto.
Rev Port Pneumol. 2010 Jan-Feb;16(1):157-61. doi: 10.1016/s0873-2159(15)30013-1.
Bullous emphysema is characterized by permanent enlargement of airspaces distal to the terminal bronchiole accompanied by destruction of alveolar walls. Several aetiologies have been described, namely deficiency of alpha1 -antitrypsin and the consumption of tobacco. With the exception of the deficiency of alpha1 -antitrypsin, some cases of bullous emphysema in the young adult continue without known aetiology. Some cases of bullous emphysema have been described, emphasising the relationship between the disease and drug consumption. The association possibly creates the conditions for the development of large lung bullae, with particular exuberance for the superior lobes. The authors describe two clinical cases of young patients, with history of consumption of smoked substance abuse and bullous emphysema.
大疱性肺气肿的特征是终末细支气管远端的气腔永久性扩大，并伴有肺泡壁破坏。已描述了几种病因，即α1-抗胰蛋白酶缺乏和吸烟。除α1-抗胰蛋白酶缺乏外，一些年轻成人的大疱性肺气肿病例病因不明。已描述了一些大疱性肺气肿病例，强调了该疾病与药物使用之间的关系。这种关联可能为大肺大疱的形成创造条件，在上叶尤为明显。作者描述了两例年轻患者的临床病例，他们有吸食滥用物质和大疱性肺气肿病史。
