Goldstein D S, Karpel J P, Appel D, Williams M H
Chest. 1986 Feb;89(2):266-9. doi: 10.1378/chest.89.2.266.
Among a large group of users of illicit intravenous drugs, the incidence of bullous pulmonary damage was noted to be 2 percent (6/387). Bullous damage was significantly different in the drug users than in those who did not use drugs. The drug users were significantly younger than the nonusers, their bullae were large and confined to the upper lobes, and alpha 1-antitrypsin deficiency was very unlikely. These features strongly implicate intravenous drug abuse in the pathogenesis of these patients' bullous pulmonary damage.
在一大群非法静脉注射毒品使用者中，发现大疱性肺损伤的发生率为2%（6/387）。吸毒者的大疱性损伤与未吸毒者有显著差异。吸毒者比未吸毒者明显年轻，他们的肺大疱较大且局限于上叶，α1抗胰蛋白酶缺乏的可能性极小。这些特征强烈提示静脉注射毒品滥用是这些患者大疱性肺损伤发病机制中的一个因素。
