Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Mod Rheumatol. 2010 Apr;20(2):123-9. doi: 10.1007/s10165-009-0257-y. Epub 2010 Jan 8.
Annular erythema has been recognized to be a specific, cutaneous manifestation associated with Sjögren's syndrome. Based on a search of the literature up to 2007, annular erythema with Sjögren's syndrome (AESS) preferentially occurs in Asian but not in Western populations. However, the precise clinical course and standard regimen for the management of AESS have remained obscure, primarily because of its rare occurrence in Western populations and the fact that most Asian cases are isolated reports. In this study, 28 cases of AESS from our department and 92 cases distilled from the literature were enrolled in a retrospective study to evaluate the clinical characteristics and most desirable management of this skin manifestation in Sjögren's syndrome. We found that 75% of all cases with AESS were positive for both anti-SSA and anti-SSB antibodies. Multiple therapeutic options are available to treat AESS, including oral steroids. Several anti-malaria drugs or tacrolimus ointment have also been reported to be effective against AESS. AESS is a distinct clinical entity, and a small dose of prednisolone (approx. 10 mg) is sufficient to control diseases activity, except in some cases with systemic manifestations, and this treatment has a more rapid clinical effect than topical steroids.
环状红斑已被确认为干燥综合征的一种特定皮肤表现。截至 2007 年的文献检索结果显示，环状红斑伴干燥综合征（AESS）主要发生在亚洲人群中，而不是西方人群中。然而，由于 AESS 在西方人群中罕见，且大多数亚洲病例为孤立报告，因此其确切的临床病程和管理标准方案仍不清楚。在这项研究中，我们部门的 28 例 AESS 病例和从文献中提取的 92 例病例被纳入回顾性研究，以评估干燥综合征中这种皮肤表现的临床特征和最理想的治疗方法。我们发现，所有 AESS 病例中有 75%同时存在抗 SSA 和抗 SSB 抗体阳性。有多种治疗选择可用于治疗 AESS，包括口服类固醇。也有报道称几种抗疟药物或他克莫司软膏对 AESS 有效。AESS 是一种独特的临床实体，小剂量泼尼松（约 10mg）足以控制疾病活动，除非有一些伴有全身表现的病例，并且这种治疗的临床效果比局部类固醇更快。
