基因组重组模拟以及DNA序列多样性对簇形成和重组可检测性的影响：一种科学工作流程方法。
Simulation of genomic recombination and the influence of DNA sequence diversity on cluster formation and detectability of recombination: a scientific workflow method.
作者信息
Alhiyafi Jamal, Lu Shiyong, Ram Jeffrey L
机构信息
Department of Computer Science, Wayne State University, 430 State Hall, 5143 Cass Avenue, Detroit, MI 48202, USA.
出版信息
Int J Comput Biol Drug Des. 2009;2(1):81-99. doi: 10.1504/ijcbdd.2009.027585.
The detection of recombination from DNA sequences is relevant to the understanding of evolutionary and molecular genetics. We developed a Recombination Simulation Scientific Workflow System (RSSWS) for simulating recombination and using GENECONV to test the effect of pairwise differences in a diverse population on the detectability of recombination. Decreases in recombination rate owing to pairwise differences resulted in population clusters analogous to sympatric speciation under specific conditions and decreases in detectability of recombination, a phenomenon that we call 'cryptic recombination'. This computational method demonstrated the value of scientific workflow methods for analysing a complex process and data driven problem.
从DNA序列中检测重组与理解进化和分子遗传学相关。我们开发了一个重组模拟科学工作流系统（RSSWS），用于模拟重组，并使用GENECONV来测试不同群体中两两差异对重组可检测性的影响。由于两两差异导致的重组率降低，在特定条件下会产生类似于同域物种形成的种群聚类，并降低重组的可检测性，我们将这种现象称为“隐性重组”。这种计算方法证明了科学工作流方法在分析复杂过程和数据驱动问题方面的价值。
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