具有增强细胞毒性活性的二氟钛配合物。
Titanocene difluorides with improved cytotoxic activity.
机构信息
Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Germany.
出版信息
Inorg Chem. 2010 Feb 15;49(4):1292-4. doi: 10.1021/ic9022163.
PMID:20055428
Abstract
Titanocene difluorides can be obtained by halide metathesis of the respective titanocene dichlorides with trimethyltin fluoride (Me(3)SnF), giving access to a new class of cytotoxic active substances. Furthermore, an improved method for the synthesis of diaryl-substituted titanocene dichlorides is presented.
摘要
二氟二茂钛可以通过相应的二茂钛二氯化物与三甲基氟化锡（Me(3)SnF）的卤化物交换反应得到，这为新型细胞毒性活性物质的合成提供了可能。此外，本文还提出了一种改进的二芳基取代二茂钛二氯化物的合成方法。
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