新型高增殖活性的钛茂衍生物对抗乳腺癌细胞。
New titanocene derivatives with high antiproliferative activity against breast cancer cells.
机构信息
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Italy.
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Italy.
出版信息
Bioorg Med Chem Lett. 2014 Jan 1;24(1):136-40. doi: 10.1016/j.bmcl.2013.11.058. Epub 2013 Dec 3.
The synthesis and characterization of some new titanocene-complexes, having a ethenyl-phenoxide or a benzyl group as substituents of the cyclopentadienyl rings, are reported. The synthesized compounds have been evaluated for their cytotoxic potential against two human breast cancer cell lines, that is: MCF7 and SkBr3. Most of these compounds have shown significant cytotoxic effects, compared to cisplatin, in MTT-based cell tests.
报告了一些新型二茂钛配合物的合成和表征，这些配合物的环戊二烯基环上有乙烯基-苯氧基或苄基取代基。合成的化合物已经在基于 MTT 的细胞试验中针对两种人乳腺癌细胞系 MCF7 和 SkBr3 评估了它们的细胞毒性潜力。与顺铂相比，这些化合物中的大多数在 MTT 细胞试验中表现出显著的细胞毒性作用。
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