Laboratoire de Parasitologie-Mycologie, CHU de Saint Etienne, Hôpital Nord, Saint Etienne, France.
Med Mycol. 2010 Feb;48(1):197-200. doi: 10.3109/13693780902717018.
We describe the development of resistance in an Aspergillus fumigatus strain, originally sensitive to itraconazole and voriconazole, recovered from a case of pulmonary aspergilloma treated with voriconazole. A G448S mutation on the cyp51A gene was detected by sequencing. Frequent culture and in vitro antifungal susceptibility testing is suggested for early detection of the development of multi-azole resistance in patients on long-term therapy for A. fumigatus infections.
我们描述了一株烟曲霉菌株的耐药性发展，该菌株最初对伊曲康唑和伏立康唑敏感，从一例用伏立康唑治疗的肺曲霉瘤病例中分离得到。通过测序检测到 cyp51A 基因上的 G448S 突变。建议对长期接受烟曲霉感染治疗的患者进行频繁的培养和体外抗真菌药敏试验，以早期发现多唑类耐药性的发展。
